Senior Scientist I, Peptide Early Phase Analytical R&D

Role Summary

The Senior Scientist I will implement and execute novel scientific research and development, independently develop and optimize new methods to generate reliable data in a timely manner, and demonstrate broad technical expertise. They will support early phase development of New Chemical Entities (NCEs), particularly synthetic peptides, in both the preclinical and clinical development spaces, and collaborate with the global Analytical R&D organization and cross-functional partners. This role focuses on transitioning NCEs from Discovery into Development Sciences and will independently serve as an Analytical Research and Development representative in a highly cross-functional team. Candidates should be comfortable discussing organic chemistry topics relevant to analytical chemistry, and experience with peptide development is required; chromatographic analysis (HPLC/GC) and Mass Spectrometry are highly preferred.

Responsibilities

• Responsible for efficiently leading and supporting new peptide product development, from an analytical perspective, while working with cross-functional areas to advance projects through the development pipeline.
• Support new peptide product development with advanced analytics to drive the pipeline and impactful research initiatives.
• Utilize understanding of a range of analytical techniques to conduct research and development studies related to synthetic-molecule drug substances, impurities, and impurity profiling.
• Highly autonomous and productive in performing laboratory research and/or method development, requiring only minimal direction from or interaction with supervisor.
• Initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• Process, interpret, and visualize data to facilitate project team decisions.
• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates.
• Raises the bar and is never satisfied with the status quo.

Qualifications

• Strong technical background in peptide development with excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
• Demonstrated experience with HPLC analysis and method development preferred along with expertise and fundamental understanding of spectroscopic techniques as they relate to peptide development and small molecules.
• Comfortable discussing organic chemistry topics within analytical R&D and with partner functions. Hands-on experience with synthetic organic chemistry preferred.
• Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
• Experience in the use of computerized data handling systems.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
• Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.
• Builds strong relationships with peers and cross-functionally with partners outside of the team to enable higher performance.
• Learns fast, grasps the "essence" and can change course quickly where indicated.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Education

• Bachelors, Masters, or Ph.D. in Chemistry (Analytical/Organic/Medicinal) or Pharmaceutical Sciences with typical minimum years of related industry experience: BS 10 years; MS 8 years; PhD 0–2 years.