Senior Scientist I, Multi-specific Biologics
AbbVie
6 hours ago
On-site
Worcester, MA
Clinical Research and Development
Discovery Biotherapeutics at AbbVie is seeking a highly skilled and self-motivated scientist to join a dynamic team supporting design, engineering, and manufacturing of multispecifics. This position impacts projects through engineering, production, and characterization of multispecific biopharmaceutical products.
Key Responsibilities:
- Responsible for design, engineering and production of multispecific biologics to support oncology
- Evaluate and integrate state-of-the-art technology to improve therapeutic production platforms; demonstrate creative “out-of-the-box” thinking to solve difficult problems
- Serve as a Multispecifics Engineering representative for cross-functional teams; contribute scientific insights across multiple projects; recognized expert in multispecifics design and production
- Serve as the Biologics lead on projects to coordinate activities and transitions from hit generation through candidate nomination
- Identify and solve technical problems independently; conceive and implement innovative process research ideas
- Ensure consistency and quality of technical reports
- Provide project updates, analysis, and advice to cross-functional teams and senior management
- Present original work internally and at internal/external scientific conferences; may author/co-author peer-reviewed papers or patents
Qualifications:
- PhD, MS, or BS in Biochemistry, Biochemical engineering or related disciplines with typically 0+ (PhD), 8+ (MS), or 10+ (BS) years of experience, ideally in multispecifics biologics engineering
- Extensive experience with protein, biologics, fragments, and multispecifics design, expression, and purification
- Experience with purification and automation instruments (e.g., Akta, Kingfisher, Hamilton)
- Sound understanding of protein expression/separation/analytical technologies; ability to explore and develop new purification approaches
- Experience with CRO coordination
- In vitro analytical techniques for protein characterization (e.g., SEC, MS, DSF); developability screening for multispecifics preferred
- Strong molecular biology skills (e.g., molecular cloning) and experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
- Knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
- Excellent organizational skills; manage multiple projects and adapt to changing priorities
- Goal-oriented team player with strong verbal and written communication skills and a can-do attitude
- Recognized in the scientific community via sustained peer-reviewed publications and patents preferred
Benefits:
- Paid time off (vacation, holidays, sick)
- Medical/dental/vision insurance and 401(k) (eligible employees)
- Eligible to participate in short-term incentive programs
Key Responsibilities:
- Responsible for design, engineering and production of multispecific biologics to support oncology
- Evaluate and integrate state-of-the-art technology to improve therapeutic production platforms; demonstrate creative “out-of-the-box” thinking to solve difficult problems
- Serve as a Multispecifics Engineering representative for cross-functional teams; contribute scientific insights across multiple projects; recognized expert in multispecifics design and production
- Serve as the Biologics lead on projects to coordinate activities and transitions from hit generation through candidate nomination
- Identify and solve technical problems independently; conceive and implement innovative process research ideas
- Ensure consistency and quality of technical reports
- Provide project updates, analysis, and advice to cross-functional teams and senior management
- Present original work internally and at internal/external scientific conferences; may author/co-author peer-reviewed papers or patents
Qualifications:
- PhD, MS, or BS in Biochemistry, Biochemical engineering or related disciplines with typically 0+ (PhD), 8+ (MS), or 10+ (BS) years of experience, ideally in multispecifics biologics engineering
- Extensive experience with protein, biologics, fragments, and multispecifics design, expression, and purification
- Experience with purification and automation instruments (e.g., Akta, Kingfisher, Hamilton)
- Sound understanding of protein expression/separation/analytical technologies; ability to explore and develop new purification approaches
- Experience with CRO coordination
- In vitro analytical techniques for protein characterization (e.g., SEC, MS, DSF); developability screening for multispecifics preferred
- Strong molecular biology skills (e.g., molecular cloning) and experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
- Knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
- Excellent organizational skills; manage multiple projects and adapt to changing priorities
- Goal-oriented team player with strong verbal and written communication skills and a can-do attitude
- Recognized in the scientific community via sustained peer-reviewed publications and patents preferred
Benefits:
- Paid time off (vacation, holidays, sick)
- Medical/dental/vision insurance and 401(k) (eligible employees)
- Eligible to participate in short-term incentive programs