Senior Scientist I - Molecular Biology
AbbVie
5 months ago
Remote friendly (Worcester, MA)
United States
$96,500 - $183,500 USD yearly
Clinical Research and Development
Senior Scientist, Cell Line Development (PDS&T)
Key Responsibilities:
- Lead the design and optimization of novel plasmid constructs for recombinant protein expression across multiple platforms.
- Optimize genetic parts, regulatory elements, and vector architecture to improve expression performance, construct behavior, and platform compatibility.
- Use molecular biology expertise for sequence analysis, construct design strategy, and experimental interpretation.
- Analyze complex sequence, construct, and experimental data to inform design decisions and next-step strategies.
- Contribute to platform optimization through innovation, process improvement, and scientific rigor.
- Support genetic characterization efforts, including work relevant to regulatory filing and development documentation.
- Partner with cross-functional teams across PDS&T and related functions to align scientific strategy with program and operational goals.
- Communicate findings, recommendations, and scientific rationale to internal stakeholders and leadership.
Qualifications:
- BS with 10+ years, MS with 8+ years, or PhD with 0–2 years.
- Strong molecular biology expertise with extensive hands-on laboratory and design experience.
- Demonstrated experience in vector design, expression construct optimization, and construct validation.
- Strong understanding of gene regulation, sequence-element-driven expression control, and vector architecture.
- Proven ability to independently design experiments, troubleshoot technical issues, and deliver high-quality scientific output.
- Excellent communication, collaboration, and organizational skills.
- Demonstrated scientific creativity, ownership, and ability to work with minimal supervision.
Preferred:
- Experience supporting cell line development or related platform development.
- Familiarity with late-stage genetic characterization and regulatory filing support.
- Experience with multiple integration systems and platform-specific construct requirements.
- Exposure to advanced sequence analysis tools/design software/high-throughput molecular biology workflows.
- Familiarity with bioinformatics, data-driven modeling, and model development.
- Experience mentoring scientists or contributing to team development.
Key Responsibilities:
- Lead the design and optimization of novel plasmid constructs for recombinant protein expression across multiple platforms.
- Optimize genetic parts, regulatory elements, and vector architecture to improve expression performance, construct behavior, and platform compatibility.
- Use molecular biology expertise for sequence analysis, construct design strategy, and experimental interpretation.
- Analyze complex sequence, construct, and experimental data to inform design decisions and next-step strategies.
- Contribute to platform optimization through innovation, process improvement, and scientific rigor.
- Support genetic characterization efforts, including work relevant to regulatory filing and development documentation.
- Partner with cross-functional teams across PDS&T and related functions to align scientific strategy with program and operational goals.
- Communicate findings, recommendations, and scientific rationale to internal stakeholders and leadership.
Qualifications:
- BS with 10+ years, MS with 8+ years, or PhD with 0–2 years.
- Strong molecular biology expertise with extensive hands-on laboratory and design experience.
- Demonstrated experience in vector design, expression construct optimization, and construct validation.
- Strong understanding of gene regulation, sequence-element-driven expression control, and vector architecture.
- Proven ability to independently design experiments, troubleshoot technical issues, and deliver high-quality scientific output.
- Excellent communication, collaboration, and organizational skills.
- Demonstrated scientific creativity, ownership, and ability to work with minimal supervision.
Preferred:
- Experience supporting cell line development or related platform development.
- Familiarity with late-stage genetic characterization and regulatory filing support.
- Experience with multiple integration systems and platform-specific construct requirements.
- Exposure to advanced sequence analysis tools/design software/high-throughput molecular biology workflows.
- Familiarity with bioinformatics, data-driven modeling, and model development.
- Experience mentoring scientists or contributing to team development.