Senior Scientist I / II – Translational Experimental Cancer Biology (OTR)

Key Responsibilities:
- Lead mechanism-of-action studies to interrogate therapeutic response and resistance in breast cancer models
- Design and execute in vitro assays to uncover intrinsic and acquired resistance pathways
- Engineer and optimize human cell line models for functional screening and mechanistic investigations
- Collaborate cross-functionally across discovery, data science, and early clinical development teams
- Analyze, interpret, and clearly communicate experimental data to drive translational insights
- Document experiments rigorously and maintain high-quality scientific records and reproducibility standards
- Stay current with emerging scientific literature and integrate new methodologies into research strategies

Essential Requirements:
- Doctor of Philosophy in biology, cancer biology, molecular biology, or related scientific discipline
- Strong expertise in cell biology and advanced molecular biology techniques
- Proven experience studying resistance to small molecule therapies using molecular approaches
- Deep understanding of hormone-driven cancer biology, including breast or prostate cancer
- Experience designing and executing in vitro assays to investigate cellular mechanisms
- Demonstrated ability to engineer and work with human cell line models
- Strong problem-solving skills and ability to interpret complex biological data
- Proven ability to collaborate effectively within multidisciplinary scientific teams

Desirable Requirements:
- Experience with data mining and computational analysis applied to biological datasets
- Familiarity with single-cell sequencing or spatial transcriptomics approaches