Senior Scientist I - Drug Metabolism

The Senior Scientist, DMPK will provide scientific leadership in the discovery of small molecule drug candidates by integrating DMPK strategy across multiple therapeutic areas.

Responsibilities:
- Lead DMPK strategy for discovery programs, aligning ADME objectives with project milestones.
- Apply fit-for-purpose in silico models, PK/PD, PBPK, and exposure–response to predict human pharmacokinetics/dose and de-risk programs.
- Integrate DMPK data with medicinal chemistry and pharmacology to guide chemical design and prioritize drug-like chemical matter.
- Propose and oversee internal/external research initiatives (study design, data analysis, documentation).
- Manage CRO partners with specialized ADME capabilities (quality, timelines, cost-effectiveness).
- Collaborate with global ADME experts to harmonize methodologies and share best practices.
- Communicate DMPK strategy, findings, and risk assessments to project teams and senior management; contribute to go/no-go decisions.
- Represent the company externally as needed (publications, conferences, scientific consortia).
- Stay current on DMPK methodologies, regulatory expectations, and modeling technologies.

Qualifications:
- BS/BA with 10+ years; or Master’s with 8+ years; or PhD with 4+ years relevant experience.
- Experience designing and conducting ADME research in pre-clinical and/or clinical development.
- Strong ADME expertise; hands-on PK and PK/PD modeling or biotransformation highly desirable.
- Strong pharmacokinetics and drug metabolism knowledge.
- Preferred: DMPK or PK/PD modeling project experience.
- Proficient scientific communication and stakeholder engagement.

Benefits:
- Medical, dental, vision; life and disability insurance; 401(k); flexible spending accounts; employee assistance; tuition reimbursement; voluntary benefits; sick time, flexible vacation, parental leave.

Application instructions:
- For accommodation requests only: call 1-855-411-5290.