Senior Scientist I, DMPK
Arrowhead Pharmaceuticals
August 17, 2026
Remote friendly (Madison, WI)
United States
Clinical Research and Development
Responsibilities:
- Develop and implement in vitro and in vivo DMPK strategies to support preclinical development across multiple indications and routes of administration.
- Manage DMPK activities, including oversight of internal resources and CRO partners, to ensure high-quality, timely data delivery.
- Design, supervise, and execute preclinical PK studies, including non-compartmental analysis (NCA); interpret data; report; communicate PK/PD insights.
- Prepare and deliver IND-enabling DMPK packages, ensuring compliance with regulatory expectations and contributing to regulatory submissions.
- Apply GLP/GCP principles and ensure appropriate documentation for regulated studies.
- Support GLP toxicokinetic (TK) study design, analysis, and reporting.
- Oversee metabolite identification in preclinical and clinical samples using high-resolution mass spectrometry (HRMS).
- Provide scientific leadership, troubleshooting, and cross-functional collaboration.
- Maintain current knowledge of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics.
Requirements:
- PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Sciences, or related discipline; at least 3 years of industry experience.
- Deep DMPK expertise; working knowledge of nucleotide/oligonucleotide drug metabolism and distribution (highly desired).
- Hands-on experience with in vitro ADME assays, in vivo PK studies, DDI evaluations, and Phoenix WinNonlin.
- LC–MS/MS and HRMS experience, ideally for oligonucleotide therapeutics.
- Strong background in organic chemistry, biochemistry, and drug biotransformation.
- Demonstrated drug development experience and understanding of regulatory processes.
- Excellent communication skills; ability to interpret and present complex scientific data clearly.
Benefits/Pay:
- Wisconsin pay range: $115,000 USD - $140,000 USD.
- Competitive salaries and an excellent benefits package.
Application instructions:
- Candidates must have current, valid authorization to work in the country where this role is located.
- Develop and implement in vitro and in vivo DMPK strategies to support preclinical development across multiple indications and routes of administration.
- Manage DMPK activities, including oversight of internal resources and CRO partners, to ensure high-quality, timely data delivery.
- Design, supervise, and execute preclinical PK studies, including non-compartmental analysis (NCA); interpret data; report; communicate PK/PD insights.
- Prepare and deliver IND-enabling DMPK packages, ensuring compliance with regulatory expectations and contributing to regulatory submissions.
- Apply GLP/GCP principles and ensure appropriate documentation for regulated studies.
- Support GLP toxicokinetic (TK) study design, analysis, and reporting.
- Oversee metabolite identification in preclinical and clinical samples using high-resolution mass spectrometry (HRMS).
- Provide scientific leadership, troubleshooting, and cross-functional collaboration.
- Maintain current knowledge of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics.
Requirements:
- PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Sciences, or related discipline; at least 3 years of industry experience.
- Deep DMPK expertise; working knowledge of nucleotide/oligonucleotide drug metabolism and distribution (highly desired).
- Hands-on experience with in vitro ADME assays, in vivo PK studies, DDI evaluations, and Phoenix WinNonlin.
- LC–MS/MS and HRMS experience, ideally for oligonucleotide therapeutics.
- Strong background in organic chemistry, biochemistry, and drug biotransformation.
- Demonstrated drug development experience and understanding of regulatory processes.
- Excellent communication skills; ability to interpret and present complex scientific data clearly.
Benefits/Pay:
- Wisconsin pay range: $115,000 USD - $140,000 USD.
- Competitive salaries and an excellent benefits package.
Application instructions:
- Candidates must have current, valid authorization to work in the country where this role is located.