Senior Scientist I, DMPK

Role: Senior Scientist, DMPK, focusing on advancing Arrowhead's RNAi therapeutics pipeline by leading preclinical pharmacokinetic and drug metabolism studies. Responsibilities: develop and execute in vitro and in vivo DMPK strategies across multiple indications, manage internal and CRO resources to ensure high-quality data, interpret complex PK/PD data, and contribute to IND-enabling packages while ensuring regulatory compliance. Requirements: PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Sciences, or related field; minimum 3 years industry experience; expertise in DMPK, including oligonucleotide metabolism, in vitro ADME, in vivo PK, and LC–MS/MS techniques. Preferred skills: knowledge of regulatory processes, strong communication skills, and experience with high-resolution mass spectrometry. HighValue: RNAi therapeutics, oligonucleotide drug modalities, preclinical stage, PK/PD, GLP/GCP principles, CRO oversight, data interpretation for INDs, based in Wisconsin with potential collaboration across research sites.