Senior Scientist, I
AbbVie
5 hours ago
On-site
South San Francisco, CA
Clinical Research and Development
Senior Scientist I — Biologics Drug Product Development (South San Francisco, CA)
Responsibilities:
- Lead end-to-end formulation and process development for liquid and lyophilized biologic drug products.
- Plan and execute DoE-driven studies; assess clinical in-use stability; model degradation pathways.
- Establish fit-for-purpose analytical strategies using protein characterization and stability methods (SEC, CE-SDS, icIEF, HIAC, MFI, DLS).
- Develop stable, fit-for-purpose drug products through formulation, process development, and clinical in-use studies.
- Support testing of representative stability lots for drug substance and drug product shelf-life extension.
- Generate and document high-quality data in an electronic lab notebook.
- Accumulate/organize experimental data, recommend analyses/interpretations, and communicate findings in presentations, technical reports, and regulatory documents.
- Formulate conclusions and design follow-on experiments based on multidisciplinary data.
- Drive innovation and continuously enhance capabilities and business processes.
- Initiate scientifically meaningful investigation areas that can be integrated into R&D programs.
- Collaborate in an agile team with minimal direction; represent the function in cross-functional and cross-site technical teams.
- Adhere to corporate standards for safety, controlled drug handling, and GxP compliance (where applicable).
Qualifications:
- Ph.D. in chemical engineering, pharmaceutical sciences, material science, analytical sciences, or equivalent; 0–3 years experience, or BS/MS with 8–10 years relevant biotechnology/pharma experience.
- Strong background in protein formulation principles, drug product degradation pathways, lyophilization, unit operations, and characterization approaches.
- Hands-on analytical experience preferred: SEC, CE-SDS, icIEF, HIAC, MFI, DLS (and related methods).
- Desired experience developing fit-for-purpose analytical characterization techniques.
- Highly desirable prior experience developing protein product formulations.
- Detail-oriented, highly organized; ability to drive innovative science and solve complex problems.
- Excellent communication and written skills.
Benefits:
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) for eligible employees.
- Eligible to participate in short-term incentive programs.
Application instructions:
- Not provided in the job description text.
Responsibilities:
- Lead end-to-end formulation and process development for liquid and lyophilized biologic drug products.
- Plan and execute DoE-driven studies; assess clinical in-use stability; model degradation pathways.
- Establish fit-for-purpose analytical strategies using protein characterization and stability methods (SEC, CE-SDS, icIEF, HIAC, MFI, DLS).
- Develop stable, fit-for-purpose drug products through formulation, process development, and clinical in-use studies.
- Support testing of representative stability lots for drug substance and drug product shelf-life extension.
- Generate and document high-quality data in an electronic lab notebook.
- Accumulate/organize experimental data, recommend analyses/interpretations, and communicate findings in presentations, technical reports, and regulatory documents.
- Formulate conclusions and design follow-on experiments based on multidisciplinary data.
- Drive innovation and continuously enhance capabilities and business processes.
- Initiate scientifically meaningful investigation areas that can be integrated into R&D programs.
- Collaborate in an agile team with minimal direction; represent the function in cross-functional and cross-site technical teams.
- Adhere to corporate standards for safety, controlled drug handling, and GxP compliance (where applicable).
Qualifications:
- Ph.D. in chemical engineering, pharmaceutical sciences, material science, analytical sciences, or equivalent; 0–3 years experience, or BS/MS with 8–10 years relevant biotechnology/pharma experience.
- Strong background in protein formulation principles, drug product degradation pathways, lyophilization, unit operations, and characterization approaches.
- Hands-on analytical experience preferred: SEC, CE-SDS, icIEF, HIAC, MFI, DLS (and related methods).
- Desired experience developing fit-for-purpose analytical characterization techniques.
- Highly desirable prior experience developing protein product formulations.
- Detail-oriented, highly organized; ability to drive innovative science and solve complex problems.
- Excellent communication and written skills.
Benefits:
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) for eligible employees.
- Eligible to participate in short-term incentive programs.
Application instructions:
- Not provided in the job description text.