Senior Scientist, Gene Delivery and Editing Process Development , Cell Therapy Development

Role: Lead formulation and drug product development for gene delivery and engineered cell therapy modalities, including LVV, AAV, mRNA, and LNP systems. Responsibilities: design and execute stability studies across liquid, frozen, and lyophilized formats; optimize excipient, buffer, cryoprotectant, and surfactant systems from first principles; develop lyophilization and cryopreservation protocols; characterize stability mechanisms using biophysical techniques; support technology transfer, process scale-up, and regulatory documentation. Requirements: Ph.D. in Pharmaceutical Sciences, Chemistry, Biochemistry, or related; 3+ years (Ph.D.), 6+ years (M.S.), or 10+ years (B.S.) in formulation or drug development, with expertise in biologic stability, freeze/thaw, lyophilization, and biophysical characterization (e.g., DLS, DSC). Preferred: hands-on lyophilization cycle development, thermostabilization, subvisible particle analysis, and familiarity with sterile manufacturing processes. High-Value: focus on gene therapy and cell therapy modalities, advanced modalities, early to late-stage development, cGMP compliance, collaboration with process development, analytical, manufacturing, and external CROs/CMOs. Work setup: not specified.