Senior Scientist, Functional Genomics

Role Summary

Senior Scientist, Functional Genomics based in Cambridge, MA. Drive the application of functional genomics target ID and validation to advanced disease models to elucidate disease mechanisms and discover novel targets across immunology, ophthalmology, neurology, oncology, and rare disease. Collaborate with therapeutic area colleagues to advance functional genomics target discovery and validation and develop new screening workflows in advanced disease models including primary cells, iPSC-derived cells, and co-culture/organoid systems.

Responsibilities

• Independently perform experiments, including pooled and arrayed CRISPR screens, in human cellular disease models to validate targets and understand mechanism of action.
• Develop cellular and molecular assays to study disease processes and validate targets in innovative disease models such as primary or iPSC-derived cells, co-culture systems, or organoids.
• Innovate in functional genomics technology by refining, scaling, or automating experimental methodologies to systematically explore gene function in disease contexts.
• Collaborate closely with therapeutic area experts to advance target discovery and in vitro disease modeling.
• Communicate your work through scientific publications, patent and regulatory filings, and presentations at internal and external meetings.

Qualifications

• Ph.D. or equivalent experience in cell biology, molecular biology, genomics, or related field. Postdoctoral training and/or industry experience will be highly valued.
• Hands-on experience in CRISPR genome editing or screening and disease modeling, such as in primary or iPSC-derived cells, co-culture systems, or organoids, is key.
• Experience in target or drug discovery, especially in immunology, ophthalmology, or neurology, would be highly valued.
• Experience in high-throughput assay development, screening platforms and robotics, flow cytometry, imaging, and/or computational data analysis would also be valued.
• Excellent communication, organizational, and team skills with a track record of success working collaboratively across disciplines.