Senior Scientist - Experimental Protein Design for Target Discovery
Amgen
August 12, 2026
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Senior Scientist – Experimental Protein Design for Target Discovery
What You Will Do
- Build and lead high-throughput platforms for binder generation, translating computational protein designs into experimentally validated minibinders and antibodies across pre-discovery targets.
- Focus on production, experimental validation, and characterization of computationally designed de novo binders.
- Create scalable binder libraries for multiplexed phenotypic screening; develop multispecific tool molecules; provide tool reagents for early-stage target characterization.
Key Responsibilities
- Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.
- Lead high-throughput workflows for binder expression, purification, and characterization, including cellular assays for binder–target evaluation.
- Partner with molecular biology teams to establish construct generation and binder library production workflows for individual characterization and pooled library screening.
- Format de novo binders into appropriate modalities (e.g., multispecifics) to test biological hypotheses.
- Analyze and interpret experimental data to guide iterative design-build-test cycles.
Basic Qualifications
- PhD (Doctorate) in a relevant field OR PharmD OR MD with relevant post-doc experience in Protein Engineering OR Master’s with 3 years Protein Engineering experience OR Bachelor’s with 5 years Protein Engineering experience.
Preferred Qualifications
- PhD in Biochemistry/Protein Engineering/Bioengineering/Structural Biology or related field with postdoctoral experience.
- High-throughput/library-based expression, purification, and biochemical/biophysical characterization of engineered proteins (antibodies/minibinders/scaffolds); experience with cell-free, E. coli, and mammalian expression is a plus.
- Binder hit validation using flow cytometry and SPR; cellular functional assay development.
- Designed binders or protein–protein interaction engineering experience; structure–function knowledge.
- Collaboration with computational protein design teams; translating in silico designs into testable reagents.
- Automation/high-throughput experimentation; phenotypic screening/receptor biology/early target characterization.
- Strong organizational and communication skills; cross-functional teamwork.
Application Instructions
- Apply via careers.amgen.com.
What You Will Do
- Build and lead high-throughput platforms for binder generation, translating computational protein designs into experimentally validated minibinders and antibodies across pre-discovery targets.
- Focus on production, experimental validation, and characterization of computationally designed de novo binders.
- Create scalable binder libraries for multiplexed phenotypic screening; develop multispecific tool molecules; provide tool reagents for early-stage target characterization.
Key Responsibilities
- Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.
- Lead high-throughput workflows for binder expression, purification, and characterization, including cellular assays for binder–target evaluation.
- Partner with molecular biology teams to establish construct generation and binder library production workflows for individual characterization and pooled library screening.
- Format de novo binders into appropriate modalities (e.g., multispecifics) to test biological hypotheses.
- Analyze and interpret experimental data to guide iterative design-build-test cycles.
Basic Qualifications
- PhD (Doctorate) in a relevant field OR PharmD OR MD with relevant post-doc experience in Protein Engineering OR Master’s with 3 years Protein Engineering experience OR Bachelor’s with 5 years Protein Engineering experience.
Preferred Qualifications
- PhD in Biochemistry/Protein Engineering/Bioengineering/Structural Biology or related field with postdoctoral experience.
- High-throughput/library-based expression, purification, and biochemical/biophysical characterization of engineered proteins (antibodies/minibinders/scaffolds); experience with cell-free, E. coli, and mammalian expression is a plus.
- Binder hit validation using flow cytometry and SPR; cellular functional assay development.
- Designed binders or protein–protein interaction engineering experience; structure–function knowledge.
- Collaboration with computational protein design teams; translating in silico designs into testable reagents.
- Automation/high-throughput experimentation; phenotypic screening/receptor biology/early target characterization.
- Strong organizational and communication skills; cross-functional teamwork.
Application Instructions
- Apply via careers.amgen.com.