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Senior Scientist - Experimental Protein Design for Target Discovery

Amgen
August 29, 2026
Full-time
Remote friendly (South San Francisco, CA)
Worldwide
Other
Role: Senior Scientist leading experimental protein design for target discovery, focusing on translating computational designs into validated minibinders and antibodies. Responsibilities: develop high-throughput workflows for binder expression, purification, characterization, and assay development; collaborate with molecular biology teams for construct and library generation; design multispecific binders to probe biology; analyze data to guide iterative design cycles. Requirements: PhD in Biochemistry, Protein Engineering, Structural Biology, or related field with postdoctoral experience, or equivalent with industry experience; expertise in protein expression, purification, biochemical/biophysical characterization of engineered proteins, and validation using flow cytometry and SPR; experience with designed binders, protein–protein interactions, and automation platforms preferred. High-Value: focus on de novo binder development for diverse targets, early-stage target characterization, high-throughput experimental methods, and collaboration with computational design teams. WorkSetup: not specified; role likely involves cross-functional team interactions.