Senior Scientist - Computational Protein Design

Role: Senior Scientist specializing in Computational Protein Design at Amgen, focused on developing automated machine learning workflows for large-scale binder creation to support discovery across multiple targets in biotherapeutics. Responsibilities: design and automate scalable pipelines for de novo protein library generation, supporting multiplexed screening and receptor discovery; collaborate with experimental and data teams for rapid validation; contribute to shared computational tools and best practices. Requirements: PhD or equivalent in Computational Biology, Structural Biology, Bioengineering, Biophysics, or Computer Science with relevant postdoctoral experience or extensive industry experience; strong programming skills in Python; experience with AI/ML tools like AlphaFold, ProteinMPNN, RFdiffusion; demonstrated expertise in computational protein design, including binder and antibody development; familiarity with high-throughput design workflows, structure-function relationships, and integration with experimental validation. Preferred: experience with cloud/HPC, multiplexed library design, protein-protein interactions, and cross-functional team collaboration. HighValue: biologics, protein engineering, AI/ML-driven design, multiple therapeutic targets, cross-disciplinary collaboration, emphasis on scalable automation.