Senior Scientist, Computational Biology

Role: Senior Scientist in Computational Biology focusing on high-dimensional data analysis to support early drug discovery at Denali. Objectives include defining and executing computational strategies across Discovery, collaborating with scientists to analyze in vitro and in vivo experiments, and contributing to portfolio advancement. Responsibilities involve expert analysis of single-cell/nucleus transcriptomics, development of analytical workflows, managing external partners, and communicating findings for regulatory and publication purposes. Requirements: PhD in Computational Biology, Bioinformatics, or related field; 3+ years industry experience analyzing single-cell RNA-seq and other high-dimensional data; proficiency in R/Python, experience with tools like Seurat, Scanpy, and version control; strong publication record and problem-solving skills. Preferred: experience with proteomics, mass spectrometry, genetics; dashboard development. High-value: expertise in single-cell transcriptomics, genomic datasets, cross-functional collaboration, supporting early-stage research from target validation through IND-enabling studies. Work setup: Not specified; salary range $147K-$191K; includes comprehensive benefits.