Senior Scientist Chemistry
Bristol Myers Squibb
5 hours ago
On-site
San Diego, CA
Clinical Research and Development
Responsibilities:
- Design and synthesize novel peptide/small-molecule compounds for SAR campaigns.
- Develop SAR on assigned projects; design/synthesize key target molecules to test chemical/biological hypotheses.
- Independently plan and execute organic synthesis routes for complex molecules; use purification/analytical tools for characterization.
- Collaborate with interdisciplinary teams to support lead identification/optimization.
- Work with chemists, DMPK, imaging, and in vitro/in vivo teams to generate target compounds to support the screening funnel.
- Support target selection and initiation of new RPT/TRP projects.
- Stay current on RPT literature; contribute ideas to advance the field.
- Contribute to IP filings and drafting publications/presentations; present findings and project updates.
- Adhere to safety/regulatory standards; identify external partners/KOLs; supervise junior scientists.
Qualifications:
- PhD in synthetic organic/peptide/medicinal chemistry with 4+ years post-PhD/postdoc OR BS with 15+ years in pharma/biotech R&D.
- Highly desirable: experience in targeted cancer therapy modalities (RPTs, ADCs, PDCs).
Required/Preferred Skills:
- Strong modern synthetic organic/peptide/med chem expertise; high lab productivity.
- Drug design/SAR/ADME-PK understanding; strong technical problem-solving.
- Ability to interpret data, plan experiments without supervision, and collaborate/cross-functionally.
- Excellent written/oral communication and ability to supervise junior scientists.
Benefits (as listed): Health coverage (medical/pharmacy/dental/vision); wellbeing support; 401(k); disability/life/accident insurance; paid time off (flexible time off for US exempt employees or vacation/holidays for other groups).
- Design and synthesize novel peptide/small-molecule compounds for SAR campaigns.
- Develop SAR on assigned projects; design/synthesize key target molecules to test chemical/biological hypotheses.
- Independently plan and execute organic synthesis routes for complex molecules; use purification/analytical tools for characterization.
- Collaborate with interdisciplinary teams to support lead identification/optimization.
- Work with chemists, DMPK, imaging, and in vitro/in vivo teams to generate target compounds to support the screening funnel.
- Support target selection and initiation of new RPT/TRP projects.
- Stay current on RPT literature; contribute ideas to advance the field.
- Contribute to IP filings and drafting publications/presentations; present findings and project updates.
- Adhere to safety/regulatory standards; identify external partners/KOLs; supervise junior scientists.
Qualifications:
- PhD in synthetic organic/peptide/medicinal chemistry with 4+ years post-PhD/postdoc OR BS with 15+ years in pharma/biotech R&D.
- Highly desirable: experience in targeted cancer therapy modalities (RPTs, ADCs, PDCs).
Required/Preferred Skills:
- Strong modern synthetic organic/peptide/med chem expertise; high lab productivity.
- Drug design/SAR/ADME-PK understanding; strong technical problem-solving.
- Ability to interpret data, plan experiments without supervision, and collaborate/cross-functionally.
- Excellent written/oral communication and ability to supervise junior scientists.
Benefits (as listed): Health coverage (medical/pharmacy/dental/vision); wellbeing support; 401(k); disability/life/accident insurance; paid time off (flexible time off for US exempt employees or vacation/holidays for other groups).