Skip to main content
Merck logo

Senior Scientist, Chemistry

Merck
August 20, 2026
Full-time
Remote friendly (South San Francisco, CA)
Worldwide
Other
Role: Discovery Chemist specializing in synthetic and medicinal chemistry to design and synthesize drug candidates; contribute to target validation and lead optimization. Responsibilities: execute on chemistry strategies, develop innovative synthetic methods, analyze structure-activity relationships, and mentor team members; author scientific publications. Requirements: Ph.D. in chemistry, medicinal chemistry, or related field (expected by Summer 2027); 4-7 years’ experience in organic synthesis emphasizing methodology, catalysis, or total synthesis; strong analytical and laboratory skills including chromatography, mass spectrometry, and spectroscopy. Preferred: experience in chemical biology and chemical proteomics. High-Value: focus on novel small molecules or chemical probes, drug discovery pipeline stages, with an emphasis on innovative synthetic techniques. Collaboration: work within multidisciplinary discovery teams; external scientific engagement. Work Setup: not specified; travel 10%. The role is based in the US, with flexible immigration sponsorship options.