Senior Scientist: Bispecifics and Antibody Engineering
Regeneron
August 20, 2026
On-site
Tarrytown, NY
Clinical Research and Development
As a Senior Scientist, a typical day could require the following:
- Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity and developability.
- Perform molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.
- Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems and molecular biology/biochemical techniques (e.g., AKTA systems and chromatographic columns).
- Characterize binding affinities, binding kinetics, and stability.
- Design and implement high-throughput, properly controlled biochemical and cell-based assays (ELISA and AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).
- Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.
- Engage program stakeholders to communicate biologic designs with data updates to meet program objectives.
- Convey results to management during cross-departmental meetings and maintain timely, accurate entries using Benchling and research ELN.
This role may be a strong fit if you:
- Have expertise in myeloid, molecular, and protein biology.
- Learn new skills quickly and troubleshoot antibody production and functional assays.
- Excel in data analysis and interpretation while supporting multiple projects.
- Prioritize efforts to adapt to evolving program directions.
- Have strong organizational, communication, and presentation skills.
- Enjoy collaborating across diverse, cross-functional teams.
To be considered you must have:
- PhD in molecular biology, cell biology, biochemistry, immunology, or related field with at least 1 year of relevant academia/industry experience.
- Core hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (e.g., AKTA systems), and comprehensive protein characterization (training available for motivated learners).
- Familiarity with cell-free expression and structural AI/ML-design (preferred, not required).
Application instructions:
- Apply now.
- Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity and developability.
- Perform molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.
- Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems and molecular biology/biochemical techniques (e.g., AKTA systems and chromatographic columns).
- Characterize binding affinities, binding kinetics, and stability.
- Design and implement high-throughput, properly controlled biochemical and cell-based assays (ELISA and AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).
- Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.
- Engage program stakeholders to communicate biologic designs with data updates to meet program objectives.
- Convey results to management during cross-departmental meetings and maintain timely, accurate entries using Benchling and research ELN.
This role may be a strong fit if you:
- Have expertise in myeloid, molecular, and protein biology.
- Learn new skills quickly and troubleshoot antibody production and functional assays.
- Excel in data analysis and interpretation while supporting multiple projects.
- Prioritize efforts to adapt to evolving program directions.
- Have strong organizational, communication, and presentation skills.
- Enjoy collaborating across diverse, cross-functional teams.
To be considered you must have:
- PhD in molecular biology, cell biology, biochemistry, immunology, or related field with at least 1 year of relevant academia/industry experience.
- Core hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (e.g., AKTA systems), and comprehensive protein characterization (training available for motivated learners).
- Familiarity with cell-free expression and structural AI/ML-design (preferred, not required).
Application instructions:
- Apply now.