Senior Scientist: Bispecifics and Antibody Engineering
Regeneron
10 days ago
On-site
Tarrytown, NY
Clinical Research and Development
Responsibilities:
- Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity, and developability.
- Perform molecular/structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.
- Produce and purify novel, logic-gated alternative format antibodies using mammalian expression systems and molecular biology/biochemical techniques (e.g., AKTA systems and chromatographic columns).
- Characterize binding affinities, binding kinetics, and stability.
- Design and implement high-throughput, properly controlled biochemical and cell-based assays (ELISA, AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).
- Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.
- Engage program stakeholders to communicate biologic designs with data updates to meet program objectives.
- Convey results to management and maintain timely, accurate research records (e.g., Benchling and research ELN).
Qualifications / Required:
- PhD in molecular biology, cell biology, biochemistry, immunology, or related field.
- At least 1 year of relevant experience in academia or industry.
Skills / Preferred:
- Hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (AKTA systems), and comprehensive protein characterization.
- Familiarity with cell-free expression and structural AI/ML-design (preferred).
Application instructions:
- Apply now.
- Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity, and developability.
- Perform molecular/structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.
- Produce and purify novel, logic-gated alternative format antibodies using mammalian expression systems and molecular biology/biochemical techniques (e.g., AKTA systems and chromatographic columns).
- Characterize binding affinities, binding kinetics, and stability.
- Design and implement high-throughput, properly controlled biochemical and cell-based assays (ELISA, AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).
- Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.
- Engage program stakeholders to communicate biologic designs with data updates to meet program objectives.
- Convey results to management and maintain timely, accurate research records (e.g., Benchling and research ELN).
Qualifications / Required:
- PhD in molecular biology, cell biology, biochemistry, immunology, or related field.
- At least 1 year of relevant experience in academia or industry.
Skills / Preferred:
- Hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (AKTA systems), and comprehensive protein characterization.
- Familiarity with cell-free expression and structural AI/ML-design (preferred).
Application instructions:
- Apply now.