Senior Scientist - Biology
Novartis
4 hours ago
On-site
Cambridge, MA
Clinical Research and Development
Key responsibilities:
- Lead mechanism-of-action studies using advanced cell biology and molecular biology approaches to interrogate therapeutic response and resistance.
- Design, develop, and execute in vitro assays to elucidate key aspects of prostate cancer biology, including resistance mechanisms to emerging therapies.
- Design and engineer human cell line models for functional screening and deep mechanistic interrogation of resistance pathways.
- Collaborate with cross-functional teams; design, execute, analyze, document experiments, and communicate results.
- Stay current with scientific literature and advancements.
Essential requirements:
- B.S./M.S. in biological/biomedical sciences.
- Strong expertise in cell biology and multiple advanced molecular biology assays, preferably including clonal dynamics using barcoding technologies.
- Robust experience studying resistance to small molecule therapies using molecular biology techniques.
- Deep understanding of hormone-driven cancer cell biology (e.g., prostate and breast cancer).
- Positive attitude, agility mindset, scientific curiosity, dedication, and excellent problem-solving skills.
- Enthusiasm for scientific collaboration in a multi-disciplinary team.
Desirable requirements:
- Proficiency with data mining and computational skills.
- Experience with single-cell RNAseq and/or spatial transcriptomics.
Compensation/benefits (as stated):
- Salary expected to range between $93,000 and $174,000 per year.
- Performance-based cash incentive; eligibility for annual equity awards depending on level.
- US-based eligible employees: comprehensive health/life/disability benefits, 401(k) with company contribution and match, and time off (vacation, personal days, holidays, other leaves).
- Lead mechanism-of-action studies using advanced cell biology and molecular biology approaches to interrogate therapeutic response and resistance.
- Design, develop, and execute in vitro assays to elucidate key aspects of prostate cancer biology, including resistance mechanisms to emerging therapies.
- Design and engineer human cell line models for functional screening and deep mechanistic interrogation of resistance pathways.
- Collaborate with cross-functional teams; design, execute, analyze, document experiments, and communicate results.
- Stay current with scientific literature and advancements.
Essential requirements:
- B.S./M.S. in biological/biomedical sciences.
- Strong expertise in cell biology and multiple advanced molecular biology assays, preferably including clonal dynamics using barcoding technologies.
- Robust experience studying resistance to small molecule therapies using molecular biology techniques.
- Deep understanding of hormone-driven cancer cell biology (e.g., prostate and breast cancer).
- Positive attitude, agility mindset, scientific curiosity, dedication, and excellent problem-solving skills.
- Enthusiasm for scientific collaboration in a multi-disciplinary team.
Desirable requirements:
- Proficiency with data mining and computational skills.
- Experience with single-cell RNAseq and/or spatial transcriptomics.
Compensation/benefits (as stated):
- Salary expected to range between $93,000 and $174,000 per year.
- Performance-based cash incentive; eligibility for annual equity awards depending on level.
- US-based eligible employees: comprehensive health/life/disability benefits, 401(k) with company contribution and match, and time off (vacation, personal days, holidays, other leaves).