Senior Scientist, Antibody Conjugation

Role: Hands-on antibody conjugation scientist responsible for developing and validating bioconjugation chemistries to support Nurix's pipeline. Objectives include establishing robust, scalable conjugation protocols compatible with automation, producing conjugates (mg to multi-mg scale) for pharmacology and PK/PD studies, and collaborating across disciplines. Responsibilities encompass designing conjugation methods, executing and scaling chemical reactions, purifying conjugates via FPLC/AKTA, troubleshooting, and supporting automation workflows. Requirements: PhD in chemistry, biochemistry, or related fields, or MS/BS with 8+ years industry experience; expertise in antibody/protein bioconjugation techniques such as NHS ester, maleimide, click chemistry, site-specific conjugation, and analytical characterization (FPLC, LC-MS, DAR analysis). Preferred: experience preparing protocols for liquid handlers and working cross-functionally in a collaborative environment. High-value specifics: bioconjugation for antibody payloads in a discovery setting, scalability, automation transfer, and multidisciplinary collaboration. Work setup: lab-based role; no travel specified.