Senior Scientist, Analytical Genomics
Novartis
July 01, 2026
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities:
- Plan and perform experiments using single-cell and spatial profiling platforms.
- Implement and optimize protocols for sample preparation, library construction, and sequencing.
- Ensure rigorous documentation and reproducibility of laboratory procedures.
- Operate and maintain relevant instruments, including troubleshooting and routine care.
- Train and mentor junior staff on instrument use and protocol adherence.
- Perform initial data processing for spatial and single-cell genomics datasets using appropriate bioinformatics tools.
- Collaborate with Data Scientists to interpret results, prepare reports, and present findings internally.
- Work with cross-functional teams (molecular biologists, bioinformaticians, project leaders).
- Document work and monitor QC measures to ensure data integrity and compliance.
- Stay current with advances in single-cell and spatial genomics technologies and integrate best practices.
Essential Requirements:
- BS or MS in Molecular Biology, Genomics, Biochemistry, or related field; 4+ years hands-on experience with spatial transcriptomics and/or single-cell sequencing (not a PhD level position).
- Strong understanding of molecular biology techniques (PCR, qRT-PCR, enzymatic reactions, DNA/RNA purification and manipulation).
- Proficiency in protocol development, troubleshooting, and optimization for complex genomics assays.
- Knowledge of NGS library preparation and sequencing workflows.
Highly Desirable:
- Experience with tissue processing and imaging, IHC, and microscopy.
Application Instructions:
- Submit a CV and cover letter summarizing relevant experience with single-cell and spatial omics protocols and instrumentation.
- Plan and perform experiments using single-cell and spatial profiling platforms.
- Implement and optimize protocols for sample preparation, library construction, and sequencing.
- Ensure rigorous documentation and reproducibility of laboratory procedures.
- Operate and maintain relevant instruments, including troubleshooting and routine care.
- Train and mentor junior staff on instrument use and protocol adherence.
- Perform initial data processing for spatial and single-cell genomics datasets using appropriate bioinformatics tools.
- Collaborate with Data Scientists to interpret results, prepare reports, and present findings internally.
- Work with cross-functional teams (molecular biologists, bioinformaticians, project leaders).
- Document work and monitor QC measures to ensure data integrity and compliance.
- Stay current with advances in single-cell and spatial genomics technologies and integrate best practices.
Essential Requirements:
- BS or MS in Molecular Biology, Genomics, Biochemistry, or related field; 4+ years hands-on experience with spatial transcriptomics and/or single-cell sequencing (not a PhD level position).
- Strong understanding of molecular biology techniques (PCR, qRT-PCR, enzymatic reactions, DNA/RNA purification and manipulation).
- Proficiency in protocol development, troubleshooting, and optimization for complex genomics assays.
- Knowledge of NGS library preparation and sequencing workflows.
Highly Desirable:
- Experience with tissue processing and imaging, IHC, and microscopy.
Application Instructions:
- Submit a CV and cover letter summarizing relevant experience with single-cell and spatial omics protocols and instrumentation.