Senior Scientist– Innate Immunity & In Vitro Modeling

Role Summary

Senior Scientist – Innate Immunity & In Vitro Modeling leads research into early innate immune mechanisms shaping vaccine efficacy and reactogenicity. The role focuses on designing and executing experiments, developing in vitro and ex vivo assays and models, and collaborating across Vaccine Research & Development to advance vaccine targets and formulations.

Responsibilities

• Regularly contribute and influence at the project team level.
• Design and execute experiments to profile innate immune responses to vaccine candidates, driving candidate selection and advancement.
• Develop in vitro and ex vivo assays and models to validate biomarkers predictive of vaccine efficacy and reactogenicity.
• Develop, optimize, and perform flow cytometry and multiplex cytokine assays to support preclinical studies, and evaluate new models.
• Supervise junior colleagues in design and execution of experiments.
• Identify, troubleshoot, and optimize relevant assay systems, technologies, and readouts.
• Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetings.
• Effectively collaborate with other members of Vaccine Research & Development and supporting partner lines.

Qualifications

• Required: PhD in Immunology with 0 to 4 years of scientific/technical experience OR Master‚Äôs degree with 7 to 10 years of scientific/technical experience
• Required: Strong background in innate immunity
• Required: Track record of scientific excellence in immunology
• Required: Highly skilled with biomarker assay platforms such as immunoassays (ADCC, ADCP, ELISPOT, ELISA, Luminex, MSD)
• Required: Proficiency in multiparametric flow cytometry assays including immunophenotyping and immune-based functional assays
• Required: Expertise in primary cell immune isolation, differentiation and characterization from murine tissues and human blood
• Required: Extensive experience in innate immune cell subsets isolation and characterization using multi-color flow cytometry
• Required: Knowledge of trained immunity and systems vaccinology
• Required: Experience with human organoid vaccine models
• Required: Ability to perform complex data analysis and be a team player with strong communication skills
• Required: Strong time management and organizational skills
• Preferred: Experience with adjuvant vaccine assay development
• Preferred: Experience with coding, including writing R and Python scripts
• Preferred: Solid background in vaccine research, innate immunology, infectious diseases or related fields, and a desire to continue in a laboratory-focused role

Skills

• Biomarker biomarker assay platforms (e.g., ADCC, ADCP, ELISPOT, ELISA, Luminex, MSD)
• Multiparametric flow cytometry and immunophenotyping
• Primary cell isolation from murine tissues and human blood
• In vitro and ex vivo immunology model development
• Data analysis and interpretation
• Scientific communication and collaboration

Education

• PhD in Immunology (required) or Master‚Äôs degree with significant relevant experience

Additional Requirements

• Work Location Assignment: On Premise
• Relocation package available