Senior Scientist, Advanced Ocular In Vitro Models
Sanofi
10 days ago
Remote friendly (Cambridge, MA)
United States
$100,500 - $145,166.66 USD yearly
Clinical Research and Development
Main Responsibilities:
- Lead scientific initiatives and teams to design, develop, and validate advanced ocular in vitro models for early and late-stage ophthalmic research.
- Lead/contribute to ophthalmology drug discovery programs (target validation, translational strategy, pipeline progression).
- Establish and optimize iPSC-derived ocular differentiation protocols (e.g., RPE, RGCs, microglia, endothelial cells).
- Integrate automation/robotics to scale workflows and improve reproducibility (automated liquid handling, high-throughput imaging/data acquisition, QC/standardization for large-scale screening and 3D model generation).
- Evaluate/implement advanced technologies (co-cultures, organoids, MPS, organ-on-chip, bioprinting).
- Apply models for disease mechanisms, target validation, multi-modality therapeutics, and safety.
- Develop/validate assays for retinal degeneration, retinal immunology, and neuroinflammation.
- Influence project strategy, deliver scientific presentations/documentation, publish/present externally, and mentor junior scientists.
Education/Qualifications:
- PhD in a relevant scientific discipline; 3+ years postdoctoral experience in pharma/biopharma (industry drug discovery leadership/contribution preferred).
Required Skills/Experience:
- iPSC-based 2D/3D ocular differentiation expertise.
- Hands-on robotics/automated culture/protocol scaling.
- High-throughput pharmacological/genetic screening with iPSC-derived cells.
- qPCR, -omics, immunocytochemistry, advanced imaging and analysis; publications/patents/external presentations.
Preferred:
- Ophthalmology drug discovery experience; ocular disease expertise (AMD, glaucoma, retinal diseases).
- CRISPR screening; 3D model development (organoids/co-cultures/MPS).
- Automation of differentiation; leadership/strategic cross-functional work.
- Retinal degeneration/immunology/neuroinflammation assays; R/Python; bioengineering with microfluidics/cellular systems.
Benefits (if applicable):
- Healthcare/prevention & wellness programs; at least 14 weeks’ gender-neutral parental leave; rewards package recognizing impact.
- Lead scientific initiatives and teams to design, develop, and validate advanced ocular in vitro models for early and late-stage ophthalmic research.
- Lead/contribute to ophthalmology drug discovery programs (target validation, translational strategy, pipeline progression).
- Establish and optimize iPSC-derived ocular differentiation protocols (e.g., RPE, RGCs, microglia, endothelial cells).
- Integrate automation/robotics to scale workflows and improve reproducibility (automated liquid handling, high-throughput imaging/data acquisition, QC/standardization for large-scale screening and 3D model generation).
- Evaluate/implement advanced technologies (co-cultures, organoids, MPS, organ-on-chip, bioprinting).
- Apply models for disease mechanisms, target validation, multi-modality therapeutics, and safety.
- Develop/validate assays for retinal degeneration, retinal immunology, and neuroinflammation.
- Influence project strategy, deliver scientific presentations/documentation, publish/present externally, and mentor junior scientists.
Education/Qualifications:
- PhD in a relevant scientific discipline; 3+ years postdoctoral experience in pharma/biopharma (industry drug discovery leadership/contribution preferred).
Required Skills/Experience:
- iPSC-based 2D/3D ocular differentiation expertise.
- Hands-on robotics/automated culture/protocol scaling.
- High-throughput pharmacological/genetic screening with iPSC-derived cells.
- qPCR, -omics, immunocytochemistry, advanced imaging and analysis; publications/patents/external presentations.
Preferred:
- Ophthalmology drug discovery experience; ocular disease expertise (AMD, glaucoma, retinal diseases).
- CRISPR screening; 3D model development (organoids/co-cultures/MPS).
- Automation of differentiation; leadership/strategic cross-functional work.
- Retinal degeneration/immunology/neuroinflammation assays; R/Python; bioengineering with microfluidics/cellular systems.
Benefits (if applicable):
- Healthcare/prevention & wellness programs; at least 14 weeks’ gender-neutral parental leave; rewards package recognizing impact.