Senior Scientist, ADC Chemistry

Role Summary

Senior Scientist, ADC Chemistry in the ADC Innovation Unit. The role involves designing and synthesizing payloads, linkers, and linker-payloads for Antibody-Drug Conjugates (ADCs), with potential involvement in conjugation to antibodies. Collaboration with biology, pharmacology, and other disciplines, plus preparing presentations with progress updates and proposals for linker-payload improvements.

Responsibilities

• Work with a team designing and producing protein degraders, ADCs and other targeted therapeutics
• Design, synthesize, and purify small molecules, peptides, potent payloads, and potentially conjugate them to proteins
• Work in a safe manner, using appropriate containment for potent compounds
• Use NMR and HPLC/UPLC techniques to prove the identity and purity of prepared compounds
• Prepare presentations and work cross-functionally within the organization in various areas including formulation, drug delivery, pharmacokinetics, and pharmacodynamics
• Liaise with BioNTech partners, CROs and CDMOs

Qualifications

• Required: Ph.D. in synthetic organic chemistry, with 3 plus years of industry experience developing PROTACs, molecular glues, or other types of protein degraders
• Required: Hands-on experience preparing complex organic molecules and using HPLC, LC-MS and NMR for purification/analysis
• Required: Proven track record of creative thinking and consistent delivery as demonstrated by publications and presentations
• Required: Excellent interpersonal, networking, and communication skills
• Required: Must be able to work on site in our synthetic laboratory
• Preferred: Experience with analytical methods used in degrader development
• Preferred: Experience in molecular modeling
• Preferred: Experience in ADC chemistry