Senior Scientist - AAV (CDMS) - Analytical and Biological Mass Spectrometry (ABMS)
Regeneron
June 26, 2026
Remote friendly (Tarrytown, NY)
United States
Clinical Research and Development
A Typical Day In The Role Might Look Like
- Design, execute, and clearly communicate analytical characterization for biotherapeutics (AAV, monoclonal/bispecific antibodies, Fc-fusion proteins, and other modalities) to support drug development.
- Lead and execute characterization activities to evaluate and elucidate critical quality attributes (charge variants, size variants, post-translational modifications), with an emphasis on charge detection mass spectrometry (CDMS) and related native-MS approaches.
- Provide analytical support for cross-functional teams (formulation development, upstream/downstream process development, manufacturing) to solve drug development challenges.
- Proactively advance LC-MS characterization by developing innovative techniques that address evolving developmental needs and improve operational efficiency.
- Independently conduct sample preparation and LC-MS analyses per SOPs; document procedures and results in an electronic laboratory notebook (ELN).
- Author/review regulatory submission documents (IND, comparability, BLA) and contribute to peer-reviewed publications.
- Represent analytical development on project teams; provide subject matter expertise and communicate results internally and externally.
This Role Might Be For You If You
- Thrive in a fast-paced, collaborative environment; deliver results with efficiency and ownership.
- Quickly learn new technologies, tackle complex problems, and have a passion for science.
- Self-motivated and proactive; prioritize effectively with minimal supervision.
To be considered for this role, you must have
- BS (10+ years), MS (7+ years), or PhD (0–3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field.
- Strongly preferred: charge detection mass spectrometry (CDMS).
- Plus: LC-MS experience for extended characterization of AAV and monoclonal antibodies.
- Desired: advanced mass spectrometers (e.g., Q Exactive Plus, Q Exactive UHMR, Q-TOF), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec).
- Plus: experimental design and data analysis (e.g., molecular modeling, graphing, statistical analysis).
Application instructions
- Please copy and paste the desired job description for this role here. If you need a copy of an existing job description, reach out to TA or work with your HR Business Partner to develop one for a new role.
- Design, execute, and clearly communicate analytical characterization for biotherapeutics (AAV, monoclonal/bispecific antibodies, Fc-fusion proteins, and other modalities) to support drug development.
- Lead and execute characterization activities to evaluate and elucidate critical quality attributes (charge variants, size variants, post-translational modifications), with an emphasis on charge detection mass spectrometry (CDMS) and related native-MS approaches.
- Provide analytical support for cross-functional teams (formulation development, upstream/downstream process development, manufacturing) to solve drug development challenges.
- Proactively advance LC-MS characterization by developing innovative techniques that address evolving developmental needs and improve operational efficiency.
- Independently conduct sample preparation and LC-MS analyses per SOPs; document procedures and results in an electronic laboratory notebook (ELN).
- Author/review regulatory submission documents (IND, comparability, BLA) and contribute to peer-reviewed publications.
- Represent analytical development on project teams; provide subject matter expertise and communicate results internally and externally.
This Role Might Be For You If You
- Thrive in a fast-paced, collaborative environment; deliver results with efficiency and ownership.
- Quickly learn new technologies, tackle complex problems, and have a passion for science.
- Self-motivated and proactive; prioritize effectively with minimal supervision.
To be considered for this role, you must have
- BS (10+ years), MS (7+ years), or PhD (0–3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field.
- Strongly preferred: charge detection mass spectrometry (CDMS).
- Plus: LC-MS experience for extended characterization of AAV and monoclonal antibodies.
- Desired: advanced mass spectrometers (e.g., Q Exactive Plus, Q Exactive UHMR, Q-TOF), liquid chromatography, and data processing software (Protein Metrics, Skyline, UniDec).
- Plus: experimental design and data analysis (e.g., molecular modeling, graphing, statistical analysis).
Application instructions
- Please copy and paste the desired job description for this role here. If you need a copy of an existing job description, reach out to TA or work with your HR Business Partner to develop one for a new role.