Senior Scientist
Pfizer
5 hours ago
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
Job Responsibilities:
- Represent Pfizer’s Pharmacokinetics, Dynamics and Metabolism (PDM) group as a project team member across small molecule (including protein degraders, molecular glues) and protein therapeutics (e.g., peptides, mAbs, mAbs-conjugates, fusion proteins) R&D programs.
- Integrate ADME characterization/optimization, bioanalysis, translational PK/PD, and immunogenicity strategies into discovery objectives to advance novel chemical and biological entities.
- Collaborate in a matrix team with ADME scientists to execute experimental plans and interpret data to provide strategic directions to discovery project teams.
- Serve as PDM point-of-contact for discovery teams; apply disposition-study ADME knowledge to influence hit-to-lead, lead development, and candidate optimization.
- Partner with pharmacologists, toxicologists, PK/PD modelers, and clinical pharmacokineticists to develop translational pharmacology plans, human PK, and dose/therapeutic margin projections.
- In preclinical development: contribute to regulatory toxicology study design/execution, support regulatory dossier preparation with relevant ADME information, respond to regulatory queries, and support early clinical human PK, safety, and tolerability studies.
- Propose practical solutions to early discovery ADME/pharmacology hurdles.
How You Will Achieve It:
- Design appropriate in vitro and in vivo disposition studies to explore ADME issues across small and large molecule programs.
- Provide strategic directions through interpretation and communication of experimental ADME data.
- Use internal/external PDM resources to deliver project milestones.
- Advance scientific/technology innovation (including AI strategies) for portfolio impact.
Minimum Requirements:
- PhD and/or post-doctoral experience (or BS/MS with 8–10 years) with graduate research in drug/xenobiotic disposition (small/large molecules), medicinal chemistry, physical organic chemistry/computational ADME, biochemistry, or pharmacokinetics (quantitative pharmacodynamics modeling), plus strong scientific achievements (e.g., peer-reviewed publications).
- Excellent interpersonal, written/verbal communication, and presentation skills; able to collaborate in multidisciplinary teams.
Preferred Skills:
- Expertise in drug disposition science (small/large molecules), drug metabolism/enzymology, medicinal chemistry, protein analytics, modeling/simulation; innovative problem-solving.
- Mechanistic modeling/simulation of PK/PD data.
- Broad understanding of pharmacokinetics and small molecule/biologics concepts.
- Coding skills and/or innovative use of AI approaches in biopharmaceutical research.
Physical/Mental Requirements:
- Sitting, standing, walking, bending; ability to perform mathematical calculations and complex data analysis.
Non-standard Work Schedule/Travel:
- None needed.
Work Location:
- Hybrid. Relocation support available.
Compensation/Benefits (as stated):
- Annual base salary: $88,500.00–$147,500.00.
- Bonus target: 10.0% of base salary (Global Performance Plan).
- Benefits include 401(k) with matching contributions, retirement savings contribution, paid vacation/holidays/personal days, paid caregiver/parental and medical leave, and medical/prescription/dental/vision coverage.
Other Employment Notes (as stated):
- Candidates must be authorized to work in the U.S.; U.S. work visa sponsorship is not available for this role now or in the future.
- Represent Pfizer’s Pharmacokinetics, Dynamics and Metabolism (PDM) group as a project team member across small molecule (including protein degraders, molecular glues) and protein therapeutics (e.g., peptides, mAbs, mAbs-conjugates, fusion proteins) R&D programs.
- Integrate ADME characterization/optimization, bioanalysis, translational PK/PD, and immunogenicity strategies into discovery objectives to advance novel chemical and biological entities.
- Collaborate in a matrix team with ADME scientists to execute experimental plans and interpret data to provide strategic directions to discovery project teams.
- Serve as PDM point-of-contact for discovery teams; apply disposition-study ADME knowledge to influence hit-to-lead, lead development, and candidate optimization.
- Partner with pharmacologists, toxicologists, PK/PD modelers, and clinical pharmacokineticists to develop translational pharmacology plans, human PK, and dose/therapeutic margin projections.
- In preclinical development: contribute to regulatory toxicology study design/execution, support regulatory dossier preparation with relevant ADME information, respond to regulatory queries, and support early clinical human PK, safety, and tolerability studies.
- Propose practical solutions to early discovery ADME/pharmacology hurdles.
How You Will Achieve It:
- Design appropriate in vitro and in vivo disposition studies to explore ADME issues across small and large molecule programs.
- Provide strategic directions through interpretation and communication of experimental ADME data.
- Use internal/external PDM resources to deliver project milestones.
- Advance scientific/technology innovation (including AI strategies) for portfolio impact.
Minimum Requirements:
- PhD and/or post-doctoral experience (or BS/MS with 8–10 years) with graduate research in drug/xenobiotic disposition (small/large molecules), medicinal chemistry, physical organic chemistry/computational ADME, biochemistry, or pharmacokinetics (quantitative pharmacodynamics modeling), plus strong scientific achievements (e.g., peer-reviewed publications).
- Excellent interpersonal, written/verbal communication, and presentation skills; able to collaborate in multidisciplinary teams.
Preferred Skills:
- Expertise in drug disposition science (small/large molecules), drug metabolism/enzymology, medicinal chemistry, protein analytics, modeling/simulation; innovative problem-solving.
- Mechanistic modeling/simulation of PK/PD data.
- Broad understanding of pharmacokinetics and small molecule/biologics concepts.
- Coding skills and/or innovative use of AI approaches in biopharmaceutical research.
Physical/Mental Requirements:
- Sitting, standing, walking, bending; ability to perform mathematical calculations and complex data analysis.
Non-standard Work Schedule/Travel:
- None needed.
Work Location:
- Hybrid. Relocation support available.
Compensation/Benefits (as stated):
- Annual base salary: $88,500.00–$147,500.00.
- Bonus target: 10.0% of base salary (Global Performance Plan).
- Benefits include 401(k) with matching contributions, retirement savings contribution, paid vacation/holidays/personal days, paid caregiver/parental and medical leave, and medical/prescription/dental/vision coverage.
Other Employment Notes (as stated):
- Candidates must be authorized to work in the U.S.; U.S. work visa sponsorship is not available for this role now or in the future.