Senior Scientist 1, in Vivo Pharmacology

Role Summary

The Senior Scientist 1, In Vivo Pharmacology, will provide in vivo pharmacology support to Endocrine Discovery teams, designing, conducting, and interpreting experiments to demonstrate efficacy and toxicity of novel small molecules in animal models. The role requires a broad background in in vivo pharmacology and contributions to multiple preclinical projects, including identification of new targets.

Responsibilities

• Design, conduct, and interpret in vivo experiments to evaluate efficacy, pharmacokinetics, and safety of therapeutic candidate molecules in endocrine disease programs.
• Conceive, research, and develop new animal models of endocrine disease states.
• Troubleshoot and perform data analysis on in vivo studies with initiative and accuracy.
• Explore and evaluate new targets in endocrinology.
• Analyze and present experimental data using Prism, Excel, MS Office or comparable software.
• Present findings to cross-functional groups, program teams, and scientific conferences.
• Serve as in vivo pharmacology lead for Endocrine Discovery programs.
• Manage outsourced studies and collaborations.
• Lead and supervise junior scientists.
• Contribute to scientific publications and in vivo pharmacology reports to support regulatory filings.
• Ensure compliance with company practices and procedures, including notebooks, files, quality and regulatory guidelines, and safety standards.
• Perform timely data verification and ensure accuracy for notebooks, protocols, reports, and regulatory filings.
• Willing to work some weekends and holidays as needed.
• Other duties as assigned.

Qualifications

• Required: Ph.D. in Biology, Endocrinology, Behavioral Pharmacology, Physiology, Neuroscience, or related field with 3–5 years of relevant experience. Applicants with BS/MS may apply but must demonstrate a minimum of 15 years of significant and relevant experience.
• Required: Experience designing and conducting rodent in vivo pharmacology studies.
• Required: Experience in the pharmaceutical industry.
• Required: Hands-on proficiency in rodent handling procedures and in vivo skills (dosing by IV, PO, SC; blood and tissue collection; necropsy; etc.).
• Required: Proficiency with basic surgical techniques.
• Required: Ability to follow pre-established experimental designs and develop new methods/protocols based on current literature.
• Required: Effective communication and presentation of research results to team members and collaborators from other disciplines.
• Required: Strong work ethic, enthusiasm for animal and laboratory work, attention to detail, reliability, and ability to work weekends when necessary.
• Required: Strong written and verbal communication skills; ability to work in a multidisciplinary, fast-paced environment.
• Required: Ability to adapt to change.
• Preferred: Experience developing endocrinology in vivo models.
• Preferred: Experience with non-GLP rodent toxicity studies.
• Preferred: Experience managing direct reports.

Skills

• Data analysis and presentation using Prism, Excel, MS Office or comparable software.
• Scientific communication and collaboration across cross-functional teams.
• Leadership and mentorship of junior scientists.

Education

• Ph.D. in Biology, Endocrinology, Behavioral Pharmacology, Physiology, Neuroscience, or related discipline (or equivalent).

Additional Requirements

• Physical Demands: Ability to sit at a desk for long periods; occasional walking; lifting up to 25 lbs; laboratory environment with standard safety requirements.
• Travel: Up to 5% of time may be required.