Senior Scientist 1, Drug Product Development
Crinetics Pharmaceuticals
June 30, 2026
On-site
San Diego, CA
Clinical Research and Development
Position Summary
Crinetics Pharmaceuticals is seeking a highly skilled and motivated professional to support Drug Product Development within Technical Operations. This on-site role in San Diego will combine hands-on formulation development with management of drug product development programs, supporting formulation and process development for small molecule therapeutics for rare endocrine disorders and endocrine-related tumors.
Responsibilities
- Recommend drug product design and development using cross-functional input, including TPP.
- Plan and execute experiments supporting drug product development from preclinical through Phase 1 (and beyond).
- Develop robust, phase-appropriate formulations and support technical transfer for scalable manufacturing.
- Support technical transfer of formulation and process to external vendors; provide in-person support for critical manufacturing.
- Interpret/analyze scientific results; present findings and make product development recommendations.
- Author drug product development technical reports and relevant regulatory submission sections.
- Execute experiments in drug product development labs.
- Develop and implement lab policies, practices, and workflows for safe, high-quality lab operations.
- Maintain high-quality data acquisition and record keeping.
- Maintain equipment to ensure safe, optimal performance.
- Train personnel on lab safety, equipment use/cleaning, and study execution; other duties as assigned.
Required Qualifications
- Bachelor’s degree in pharmaceutical sciences, engineering, or related field + 10+ years relevant technical experience.
- Hands-on experience supporting oral solid dosage and first-in-human formulations.
- Expertise with oral solid dosage formulation/process equipment (e.g., blending, granulation, tablet compression, pan coating) and characterization.
- Strongly preferred: R&D scale spray drying equipment experience.
- Equipment/instrument maintenance experience (including vendor maintenance/calibration coordination).
- Safety recommendations and support for HAZOP and JSA.
- Analytical chemistry understanding (e.g., HPLC, dissolution, DSC, Karl Fischer, XRPD, SEM).
- Understanding of cGMP and ICH/regulatory guidance.
- Excellent communication and writing; team-oriented with ability to manage competing priorities.
- Safety-first mindset and high attention to detail.
Technical Knowledge
- PC and office systems; Windows, MS Office (Outlook/Word/Excel/PowerPoint), MS Project.
Benefits (as stated)
- Discretionary annual target bonus, stock options, ESPP, 401k match; medical/dental/vision/basic life; 20 days PTO; 10 paid holidays; winter company shutdown.
Crinetics Pharmaceuticals is seeking a highly skilled and motivated professional to support Drug Product Development within Technical Operations. This on-site role in San Diego will combine hands-on formulation development with management of drug product development programs, supporting formulation and process development for small molecule therapeutics for rare endocrine disorders and endocrine-related tumors.
Responsibilities
- Recommend drug product design and development using cross-functional input, including TPP.
- Plan and execute experiments supporting drug product development from preclinical through Phase 1 (and beyond).
- Develop robust, phase-appropriate formulations and support technical transfer for scalable manufacturing.
- Support technical transfer of formulation and process to external vendors; provide in-person support for critical manufacturing.
- Interpret/analyze scientific results; present findings and make product development recommendations.
- Author drug product development technical reports and relevant regulatory submission sections.
- Execute experiments in drug product development labs.
- Develop and implement lab policies, practices, and workflows for safe, high-quality lab operations.
- Maintain high-quality data acquisition and record keeping.
- Maintain equipment to ensure safe, optimal performance.
- Train personnel on lab safety, equipment use/cleaning, and study execution; other duties as assigned.
Required Qualifications
- Bachelor’s degree in pharmaceutical sciences, engineering, or related field + 10+ years relevant technical experience.
- Hands-on experience supporting oral solid dosage and first-in-human formulations.
- Expertise with oral solid dosage formulation/process equipment (e.g., blending, granulation, tablet compression, pan coating) and characterization.
- Strongly preferred: R&D scale spray drying equipment experience.
- Equipment/instrument maintenance experience (including vendor maintenance/calibration coordination).
- Safety recommendations and support for HAZOP and JSA.
- Analytical chemistry understanding (e.g., HPLC, dissolution, DSC, Karl Fischer, XRPD, SEM).
- Understanding of cGMP and ICH/regulatory guidance.
- Excellent communication and writing; team-oriented with ability to manage competing priorities.
- Safety-first mindset and high attention to detail.
Technical Knowledge
- PC and office systems; Windows, MS Office (Outlook/Word/Excel/PowerPoint), MS Project.
Benefits (as stated)
- Discretionary annual target bonus, stock options, ESPP, 401k match; medical/dental/vision/basic life; 20 days PTO; 10 paid holidays; winter company shutdown.