Senior Research Scientist, Cell Engagers

Role Summary

Senior Research Scientist, Cell Engagers. Location: Cambridge, MA. Full time with up to 20% remote work.

Responsibilities

• Contribute to discovery projects by independently designing and developing mechanistic in vitro and ex vivo experiments for oncology cell engager research to identify mechanisms of action (MoA).
• Lead from the lab to advance novel and differentiated products in collaboration with cell therapy oncology toward clinical milestones, incorporating new VŒ¥1 isolation strategies for use in cell engager programs in vitro.
• Propose novel projects based on internal results, external partners, and published reports; demonstrate leadership through effective communication of study plans, value, and results.
• Isolate and phenotype VŒ¥1 cells from blood and skin; collaborate with Cell Therapy team to incorporate new VŒ¥1 isolation strategies for use in cell engager programs in vitro.
• Use immune cell characterization and function assessment (e.g., multi-color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assays, and other molecular-based and cell-based functionality assays) to perform analysis and determine appropriate action.
• Prepare and present comprehensive technical or project reports and formal presentations and posters to internal/external audiences; contribute to IND reports and other regulatory filings.
• Maintain laboratory notebooks and comply with Takeda policies.
• Independently design cytokine fusion strategy to enhance VŒ¥1 biology for solid tumors.
• Propose additional projects based on internal/external results and published reports; assist with external collaborations/CROs and establish new protocols.

Qualifications

• Required: Master‚Äôs degree in Cancer Immunology and Immunotherapy, Cancer Sciences, or related field plus 5 years of related experience.
• Required: Experience isolating Gamma-Delta T cells from blood and tissue and researching Gamma Delta T cell culture and expansion to improve yield and cytotoxicity.
• Required: Experience developing functional and characterization experiments via flow cytometry, spectrometry, and chemiluminescence of isolated VŒ¥1 cells; analyze data and interpret results with knowledge of VŒ¥1 gamma delta cell biology.
• Required: Contribute to evaluation of novel immunotherapy products based on VŒ¥1 gamma delta cell biology.
• Required: Experience with gene engineering of VŒ¥1 cells.

Skills

• In vitro and ex vivo assay design and optimization
• Immune cell phenotyping and functional assays
• Flow cytometry, cytokine measurement, cytotoxicity assays
• Data analysis and interpretation in immunology context
• Technical reporting and scientific communication
• Project leadership and cross-functional collaboration

Education

• Master‚Äôs degree in Cancer Immunology and Immunotherapy, Cancer Sciences, or related field

Additional Requirements

• Up to 20% remote work allowed.