Senior Research Scientist, Cell Engagers

Role Summary

Senior Research Scientist, Cell Engagers. Location: Cambridge, MA. Full time with up to 20% remote work.

Responsibilities

• Contribute to discovery projects by independently designing and developing mechanistic in vitro and ex vivo experiments for oncology cell engager research to identify mechanisms of action (MoA).
• Lead from the lab to advance novel and differentiated products in collaboration with cell therapy oncology toward clinical milestones, incorporating new Vδ1 isolation strategies for use in cell engager programs in vitro.
• Propose novel projects based on internal results, external partners, and published reports; demonstrate leadership through effective communication of study plans, value, and results.
• Isolate and phenotype Vδ1 cells from blood and skin; collaborate with Cell Therapy team to incorporate new Vδ1 isolation strategies for use in cell engager programs in vitro.
• Use immune cell characterization and function assessment (e.g., multi-color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assays, and other molecular-based and cell-based functionality assays) to perform analysis and determine appropriate action.
• Prepare and present comprehensive technical or project reports and formal presentations and posters to internal/external audiences; contribute to IND reports and other regulatory filings.
• Maintain laboratory notebooks and comply with Takeda policies.
• Independently design cytokine fusion strategy to enhance Vδ1 biology for solid tumors.
• Propose additional projects based on internal/external results and published reports; assist with external collaborations/CROs and establish new protocols.

Qualifications

• Required: Master’s degree in Cancer Immunology and Immunotherapy, Cancer Sciences, or related field plus 5 years of related experience.
• Required: Experience isolating Gamma-Delta T cells from blood and tissue and researching Gamma Delta T cell culture and expansion to improve yield and cytotoxicity.
• Required: Experience developing functional and characterization experiments via flow cytometry, spectrometry, and chemiluminescence of isolated Vδ1 cells; analyze data and interpret results with knowledge of Vδ1 gamma delta cell biology.
• Required: Contribute to evaluation of novel immunotherapy products based on Vδ1 gamma delta cell biology.
• Required: Experience with gene engineering of Vδ1 cells.

Skills

• In vitro and ex vivo assay design and optimization
• Immune cell phenotyping and functional assays
• Flow cytometry, cytokine measurement, cytotoxicity assays
• Data analysis and interpretation in immunology context
• Technical reporting and scientific communication
• Project leadership and cross-functional collaboration

Education

• Master’s degree in Cancer Immunology and Immunotherapy, Cancer Sciences, or related field

Additional Requirements

• Up to 20% remote work allowed.