Senior Research Associate/ Senior Scientist, Core Research

Role Summary

We are seeking a highly qualified and motivated individual to perform basic research to increase our understanding of how ASOs target RNA to modulate the expression of genes. The position offers the opportunity to do groundbreaking science and make discoveries that will create the next generation of ASO medicines. The selected candidate will become an integral part of an interdisciplinary and energetic team of scientists in the Ionis Core Research group.

Responsibilities

• Conduct basic research to understand RNA metabolism, transcription, gene regulation, or epigenetics and how ASOs modulate gene expression
• Collaborate within an interdisciplinary team to advance Core Research projects

Qualifications

• Required: Ph.D in biochemistry, molecular biology or cell biology with at least 2 years of post-grad laboratory experience; or an M.S. with at least 3 years post-grad laboratory experience
• Required: Extensive experience in the RNA field with a focus on RNA metabolism, transcription, gene regulation, or epigenetics
• Required: Extensive experience with basic laboratory techniques such as cell culture, transfection, qPCR, cloning, and western blotting
• Required: Experience with advanced laboratory techniques frequently used in RNA research such as ChIP-seq, RNA-seq, FISH, SHAPE, and CRISPR editing
• Required: Proven track record of innovative research, including publications in top tier scientific journals
• Required: Self-starter who is a critical thinker, has a strong work ethic and is not afraid to take risks
• Required: Outstanding organizational, communication and team skills
• Required: Ability to be productive and successful in an intense work environment

Skills

• RNA biology
• Cell culture
• Transfection, qPCR, cloning, western blotting
• ChIP-seq, RNA-seq, FISH, SHAPE, and CRISPR editing
• Scientific publication track record
• Strong communication and collaboration

Education

• Ph.D in biochemistry, molecular biology or cell biology with post-graduate experience; or a M.S. with post-grad laboratory experience