Senior Research Associate I/II – In Vivo

Role Summary

Senior Research Associate I/II – In Vivo responsible for executing pivotal proof-of-concept studies in pre-clinical mouse models of inflammation, immunology, and oncology, and supporting cross-functional development of research strategy. Designs and executes in vivo/ex vivo pharmacology studies to define activity and mechanism of action of compounds. Primarily based in the Animal Care Facility with hours around 10am-6pm, including afternoon/evening and weekend dosing as part of study protocols. Opportunity to perform ex vivo/in vitro experiments to expand bench skills.

Responsibilities

• Perform basic and intermediate veterinary technical tasks in mice independently.
• Administer agents by PO, IP, and SC routes.
• Perform blood sampling via multiple routes, including submandibular bleed.
• Carry out tissue harvests at designated time points.
• Prepare compound formulations for in vivo dosing.
• Optimize and perform studies to define target biology in mouse models of inflammation, oncology, and immunity for in vivo, in vitro, and ex vivo applications.
• Maintain accurate laboratory records/notebooks, procedures, and data summaries.
• Perform evening and weekend dosing of animals as part of study protocols.
• Conduct health checks to ensure animal welfare and identify concerns.
• Carry out tissue harvests at later time points as required.
• Prepare and perform formulations for dosing studies.
• Oversee breeding programs, monitor litters, and document outcomes.
• Assist with cage changes and husbandry tasks as needed.
• Process time-sensitive biological samples.

Qualifications

• BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years of relevant industry experience.
• AALAS certification at the ALAT level preferred; LVT qualification a plus.
• Ability to work flexible hours, including evenings and weekends as needed.
• Experience handling compounds for formulation preparation with safety emphasis and calculation proficiency.
• Strong experience in animal handling, including compound administration by multiple routes, tissue and blood harvesting, and necropsy techniques; surgical techniques a plus.
• Strong organizational skills and attention to detail.
• Experience in culturing mammalian cell lines is advantageous.
• Experience with pharmacodynamics assays of mouse tissue (e.g., Western Blotting or JESS, ELISA/Mesoscale, and flow cytometry) is a plus but not required.
• Willingness to learn new benchwork skills, including sample processing and cell culture.

Skills

• In vivo pharmacology methods
• Animal handling and welfare
• Formulation preparation and dosing
• Sample collection and tissue/blood processing
• Data recording and basic data summarization
• Multi-route administration (PO, IP, SC)
• Basic to intermediate laboratory techniques for ex vivo/in vitro work

Education

• BS/MS in Biology, Pharmacology, Animal Science, or related field

Additional Requirements

• Flexible scheduling including evenings and weekends as required for study protocols