Senior Research Associate, Formulation

Role Summary

Senior Research Associate to join the Early Development team focused on oligonucleotide-based therapeutics. Contribute to the design and development of innovative drug formulations at preclinical and early clinical stages, supporting formulation screening, in vitro and in vivo formulation preparation, and process development for novel oligonucleotide candidates.

Responsibilities

• Support the design and execution of formulation studies for oligonucleotide drug products
• Perform laboratory experiments in a safe and efficient manner and record research findings in ELN
• Collaborate with analytical, process development, and manufacturing teams to ensure seamless tech transfer
• Support analytical testing and interpretation of data related to physical and chemical stability
• Contribute to the preparation of technical reports, presentations, and regulatory documentation
• Stay current with scientific literature and industry trends in oligonucleotide formulation and delivery
• Additional tasks as assigned

Qualifications

• Required: B.S. with 4 years of experience or M.S. with 2 years of experience in Chemistry or Organic Chemistry
• Preferred: Prior industry experience in oligonucleotide formulation and scale-up
• Preferred: Knowledge of analytical chemistry and basic nucleic acid chemistry
• Preferred: Experience with UPLC, LCMS and formulation characterization instruments
• Preferred: Hands-on experience with pH adjustment, UV spectroscopy, endotoxin and physical property measurement; HPLC/UPLC experience is a plus
• Strong organizational skills and attention to detail
• Excellent communication and teamwork abilities

Education

Additional Requirements

• Location: Bedford, MA (lab-based position)
• Travel: Approximately 5%