Senior Research Associate, DMPK

Role Summary

Senior Research Associate in the Drug Metabolism and Pharmacokinetic (DMPK) department performing in vitro metabolism assays, metabolite identification studies, and bioanalytical work to screen chemical entities for new drug candidates.

Responsibilities

• Perform various in vitro metabolism studies to address specific DMPK questions in drug discovery
• Develop analytical methods using LC-MS/MS to separate and detect small molecules and peptides
• Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department
• Influence discovery decisions and contribute significantly to corporate goals and project milestones
• Maintain a command of relevant scientific literature, evaluate implications for internal projects
• Maintain laboratory equipment, facilitate its use by other scientists, and keep detailed, up-to-date experimental records
• Conduct other duties as assigned

Qualifications

• Bachelor’s degree in Biological Sciences, Chemistry, or related field with at least five years of hands-on, relevant DMPK lab experience with mass spectrometry (or master’s degree with at least two years of experience)
• Experience performing metabolic stability, CYP inhibition, and metabolite ID studies in liver subcellular fractions, and preparing/analyzing samples from biological matrices using LC-MS/MS
• Proficiency in using and troubleshooting LC-MS/MS (Sciex a plus)
• Demonstrated technical proficiency, creativity, problem solving, and ability to independently plan and execute experiments while seeking guidance as needed
• Excellent interpersonal, verbal, and written communication skills
• Highly motivated to work in a fast-paced environment with a desire to learn and tackle new challenges

Education

• Specific degrees as listed in Qualifications (Bachelor’s with 5 years experience or Master’s with 2+ years experience)

Additional Requirements

• No additional travel or physical demands specified as essential in the description