Senior Research Associate
Sanofi
5 hours ago
On-site
Cambridge, MA
Clinical Research and Development
Main Responsibilities
- Lead and independently execute acute and chronic in vivo PK/PD studies in rodent models to establish exposure-response relationships and assess therapeutic efficacy.
- Design and coordinate complex dosing regimens across multiple administration routes (PO, IP, SQ, IV), including clinical observations, sample collection timing, and tissue harvesting.
- Perform advanced mouse procedures: blood micro-sampling, terminal collections, brain dissection and microdissection, and CSF collection.
- Manage large-scale in vivo studies from experimental design through data analysis and interpretation.
- Process and analyze tissue samples from in vivo studies using NULISA, MSD, ELISA, and Western Blot to assess pharmacodynamic and biological responses.
- Establish and maintain primary cell cultures and iPSC-derived tri-culture systems for compound screening and mechanistic studies.
- Use flow cytometry to characterize protein expression across cell types and conditions (sample prep, staining optimization, analysis).
- Develop and optimize plate-based cellular assays to evaluate compound activity and cellular responses.
Qualifications
Required
- Bachelor’s degree in Biochemistry, Neuroscience, Biology, or related life sciences.
- 2-4+ years of hands-on research experience in pharmaceutical/biotechnology industry.
- Experience in neuroscience research or CNS-focused drug discovery programs.
- Extensive experience executing mouse in vivo studies with multiple dosing routes and sample collection techniques.
Preferred
- Strong organizational skills and meticulous experimental documentation.
- Collaborative cross-functional mindset.
- Commitment to animal welfare and ethical research practices.
- Molecular biology foundation (Western Blot, ELISA, qPCR, protein quantification).
- Experience with NULISA or MSD multiplex immunoassays.
- Hands-on mammalian cell culture (primary cells and/or iPSC-derived systems).
- Flow cytometry experience (panel design, prep, acquisition, data analysis).
- High-content imaging and phenotypic screening experience.
- Familiarity with Incucyte live-cell analysis systems.
- GraphPad Prism (or equivalent) proficiency; electronic lab notebooks (Benchling or similar) and data management systems.
Benefits (explicitly stated)
- Health and wellbeing benefits, including high-quality healthcare, prevention/wellness programs, and at least 14 weeks’ gender-neutral parental leave.
Application instructions
- Not specified in the provided text.
- Lead and independently execute acute and chronic in vivo PK/PD studies in rodent models to establish exposure-response relationships and assess therapeutic efficacy.
- Design and coordinate complex dosing regimens across multiple administration routes (PO, IP, SQ, IV), including clinical observations, sample collection timing, and tissue harvesting.
- Perform advanced mouse procedures: blood micro-sampling, terminal collections, brain dissection and microdissection, and CSF collection.
- Manage large-scale in vivo studies from experimental design through data analysis and interpretation.
- Process and analyze tissue samples from in vivo studies using NULISA, MSD, ELISA, and Western Blot to assess pharmacodynamic and biological responses.
- Establish and maintain primary cell cultures and iPSC-derived tri-culture systems for compound screening and mechanistic studies.
- Use flow cytometry to characterize protein expression across cell types and conditions (sample prep, staining optimization, analysis).
- Develop and optimize plate-based cellular assays to evaluate compound activity and cellular responses.
Qualifications
Required
- Bachelor’s degree in Biochemistry, Neuroscience, Biology, or related life sciences.
- 2-4+ years of hands-on research experience in pharmaceutical/biotechnology industry.
- Experience in neuroscience research or CNS-focused drug discovery programs.
- Extensive experience executing mouse in vivo studies with multiple dosing routes and sample collection techniques.
Preferred
- Strong organizational skills and meticulous experimental documentation.
- Collaborative cross-functional mindset.
- Commitment to animal welfare and ethical research practices.
- Molecular biology foundation (Western Blot, ELISA, qPCR, protein quantification).
- Experience with NULISA or MSD multiplex immunoassays.
- Hands-on mammalian cell culture (primary cells and/or iPSC-derived systems).
- Flow cytometry experience (panel design, prep, acquisition, data analysis).
- High-content imaging and phenotypic screening experience.
- Familiarity with Incucyte live-cell analysis systems.
- GraphPad Prism (or equivalent) proficiency; electronic lab notebooks (Benchling or similar) and data management systems.
Benefits (explicitly stated)
- Health and wellbeing benefits, including high-quality healthcare, prevention/wellness programs, and at least 14 weeks’ gender-neutral parental leave.
Application instructions
- Not specified in the provided text.