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Senior Research Associate

Nautilus Biotechnology
5 hours ago
On-site
San Carlos, CA
$86,000 - $127,000 USD yearly
Clinical Research and Development
Responsibilities:
- Execute and optimize phage display panning campaigns to identify and enrich antigen-specific affinity reagent clones
- Perform high-throughput screening and characterization using ELISA, western blot, biolayer interferometry (BLI), and/or the Nautilus proteomics platform
- Conduct molecular cloning workflows supporting antibody reformatting, expression construct design, and recombinant protein production
- Culture mammalian cells (e.g., HEK293) for transient and stable protein expression
- Record data, track experiments, and manage reagents within a LIMS platform
- Present experimental results clearly and concisely to cross-functional teams
- Author and maintain SOPs, assay protocols, and controlled documentation
- Take on dynamic task assignments across projects as priorities evolve

Requirements:
- Bachelor’s degree or higher in Biochemistry, Molecular Biology, Cell Biology, or a related life science field
- 4–6 years of hands-on laboratory experience in antibody-based assay development and reagent characterization
- Direct experience with phage display or other affinity selection platforms
- Proficiency in ELISA, western blot, and at least one biophysical binding method (BLI or SPR)
- Practical experience with molecular cloning and mammalian cell culture
- Experience working within a LIMS or equivalent data management system
- Strong organizational skills and attention to detail; ability to manage multiple concurrent experiments
- Clear written and verbal communication skills

Preferred Skills:
- Experience with fluorescence microscopy and/or cell-based imaging assays
- Experience with automated liquid handling and magnetic bead-based workflows
- Prior experience in a fast-paced biotech or startup research setting

Compensation Range:
- $86K - $127K