Senior Research Associate 1- Cancer Biology
Bristol Myers Squibb
8 hours ago
On-site
San Diego, CA
Clinical Research and Development
Job Responsibilities
- Maintain and expand mammalian cell lines (overexpressing/knockout) and validate reagents to ensure target expression and cell line quality.
- Develop, optimize, and run biochemical and cell-based assays to support screening, characterization, and lead identification of RPT agents.
- Support assay transfer and qualification (protocol documentation, acceptance criteria, reproducibility).
- Work with radioactivity in assays in strict accordance with radiation safety protocols.
- Support biology screening/evaluation plans; partner with chemists, DMPK, imaging, and in vivo teams to implement the screening funnel and prioritize experiments.
- Maintain meticulous experimental records; independently analyze/interpret data and present plans/results.
- Contribute to experimental design and planning; collaborate with translational research and chemistry; assist with lab operation management.
Qualifications
- BS with 3–10 years or MS with 2–4+ years in Biology/Biochemistry/Molecular Biology/Pharmacology or related field; hands-on cell culture and assay development.
- Prior drug discovery project experience (industrial or academic) preferred.
Skills (Required/Preferred)
- Strong mammalian cell culture (aseptic technique) and in vitro assay development/optimization; equilibrium binding assays; assay transfer/qualification/troubleshooting (highly desirable).
- ELISA, MSD, flow cytometry, western blot, qPCR, immunohistochemistry.
- Cell line engineering (CRISPR, lentiviral transduction, stable transfection).
- GraphPad Prism for dose-response/statistics; receptor-ligand binding theory and basic pharmacology.
- Communication, organization, attention to detail.
- Ability to work with radioisotopes following safety protocols.
- AI/computational tools experience desirable; uses AI tools to improve productivity/quality.
Benefits (as stated)
- Health coverage (medical, pharmacy, dental, vision); wellbeing support programs; 401(k) and insurance/disability benefits.
- Paid Time Off (flexible time off or annual paid vacation based on employee type/location) and paid national holidays.
- Additional time off may include paid sick time, volunteer days, leaves of absence, and annual Global Shutdown.
Physical/Lab Requirements
- Laboratory environment with protective clothing, gloves, and safety glasses while working with radioactive materials.
- Maintain and expand mammalian cell lines (overexpressing/knockout) and validate reagents to ensure target expression and cell line quality.
- Develop, optimize, and run biochemical and cell-based assays to support screening, characterization, and lead identification of RPT agents.
- Support assay transfer and qualification (protocol documentation, acceptance criteria, reproducibility).
- Work with radioactivity in assays in strict accordance with radiation safety protocols.
- Support biology screening/evaluation plans; partner with chemists, DMPK, imaging, and in vivo teams to implement the screening funnel and prioritize experiments.
- Maintain meticulous experimental records; independently analyze/interpret data and present plans/results.
- Contribute to experimental design and planning; collaborate with translational research and chemistry; assist with lab operation management.
Qualifications
- BS with 3–10 years or MS with 2–4+ years in Biology/Biochemistry/Molecular Biology/Pharmacology or related field; hands-on cell culture and assay development.
- Prior drug discovery project experience (industrial or academic) preferred.
Skills (Required/Preferred)
- Strong mammalian cell culture (aseptic technique) and in vitro assay development/optimization; equilibrium binding assays; assay transfer/qualification/troubleshooting (highly desirable).
- ELISA, MSD, flow cytometry, western blot, qPCR, immunohistochemistry.
- Cell line engineering (CRISPR, lentiviral transduction, stable transfection).
- GraphPad Prism for dose-response/statistics; receptor-ligand binding theory and basic pharmacology.
- Communication, organization, attention to detail.
- Ability to work with radioisotopes following safety protocols.
- AI/computational tools experience desirable; uses AI tools to improve productivity/quality.
Benefits (as stated)
- Health coverage (medical, pharmacy, dental, vision); wellbeing support programs; 401(k) and insurance/disability benefits.
- Paid Time Off (flexible time off or annual paid vacation based on employee type/location) and paid national holidays.
- Additional time off may include paid sick time, volunteer days, leaves of absence, and annual Global Shutdown.
Physical/Lab Requirements
- Laboratory environment with protective clothing, gloves, and safety glasses while working with radioactive materials.