Senior Principal Scientist, Translational Clinical Biomarkers
Merck
12 days ago
Remote friendly (Rahway, NJ)
United States
Clinical Research and Development
Primary Responsibilities
- Lead and shape integrated immunology biomarker strategies across discovery and early-/late-stage clinical programs; define hypotheses, fit-for-purpose endpoints, and explicit linkage to key development decisions.
- Serve as biomarker strategy lead in cross-functional program teams and represent teams in governance forums.
- Drive biomarker-driven insights to inform target validation, patient selection, and go/no-go decisions.
- Translate disease biology and MoA into clinically actionable biomarker strategies (e.g., proof of biology, pharmacodynamics, precision medicine, surrogate efficacy endpoints).
- Lead biomarker sub-teams/working groups across clinical, discovery, translational, regulatory, biostatistics, and data sciences.
- Champion biomarker analysis plans; interpret complex datasets and communicate insights to stakeholders and external scientific audiences.
Qualifications
- Ph.D. or M.D. with 12+ years in Immunology or related field; experience with autoimmune diseases and/or translational medicine.
Required Experience/Skills
- Deep immunology expertise in immune-mediated/inflammatory diseases, including GI/mucosal inflammation, rheumatology, and/or dermatology.
- Proven translational track record informing clinical development decisions; experience partnering cross-functionally.
- Ability to lead in highly matrixed environments; strong analytical/problem-solving and communication skills.
- Working knowledge of biostatistics, bioinformatics, and advanced data analytics.
Preferred
- Experience advancing precision medicine strategies; direct managerial experience.
Compensation/Benefits (if applicable)
- Eligible for annual bonus and long-term incentive.
Application
- Apply at https://jobs.merck.com/us/en. Application deadline is stated on the posting. Requisition ID: R399013.
- Lead and shape integrated immunology biomarker strategies across discovery and early-/late-stage clinical programs; define hypotheses, fit-for-purpose endpoints, and explicit linkage to key development decisions.
- Serve as biomarker strategy lead in cross-functional program teams and represent teams in governance forums.
- Drive biomarker-driven insights to inform target validation, patient selection, and go/no-go decisions.
- Translate disease biology and MoA into clinically actionable biomarker strategies (e.g., proof of biology, pharmacodynamics, precision medicine, surrogate efficacy endpoints).
- Lead biomarker sub-teams/working groups across clinical, discovery, translational, regulatory, biostatistics, and data sciences.
- Champion biomarker analysis plans; interpret complex datasets and communicate insights to stakeholders and external scientific audiences.
Qualifications
- Ph.D. or M.D. with 12+ years in Immunology or related field; experience with autoimmune diseases and/or translational medicine.
Required Experience/Skills
- Deep immunology expertise in immune-mediated/inflammatory diseases, including GI/mucosal inflammation, rheumatology, and/or dermatology.
- Proven translational track record informing clinical development decisions; experience partnering cross-functionally.
- Ability to lead in highly matrixed environments; strong analytical/problem-solving and communication skills.
- Working knowledge of biostatistics, bioinformatics, and advanced data analytics.
Preferred
- Experience advancing precision medicine strategies; direct managerial experience.
Compensation/Benefits (if applicable)
- Eligible for annual bonus and long-term incentive.
Application
- Apply at https://jobs.merck.com/us/en. Application deadline is stated on the posting. Requisition ID: R399013.