Senior / Principal Scientist, Structural Biology — Target Druggability & Structure-Based Drug Design

Role: Senior or Principal Scientist in Structural Biology focusing on Target Druggability and Structure-Based Drug Design within Schrödinger's Therapeutics Group. Responsibilities: define druggability hypotheses for challenging targets by integrating structural, computational, and biophysical data; apply advanced computational methods, including AI/ML, for structure prediction and cryptic pocket detection; translate insights into experimental plans; lead structural biology efforts, managing external CROs or conducting in-house experiments; contribute to platform strategy by integrating target-tractability insights. Requirements: PhD in Structural Biology, Biophysics, Computational Chemistry, or related field; extensive hands-on experience in structure-based drug design, cryptic site detection, and pocket druggability; proficiency with AI/ML approaches, cryo-EM, X-ray crystallography; demonstrated success in assessing oral druggability of difficult targets. HighValue: expertise in computational-experimental hybrid approaches, cryptic/transient site identification, biophysical validation, and collaboration across multidisciplinary teams. WorkSetup: not specified; salary range $135,000–$190,000, with comprehensive benefits.