Senior Principal Scientist, Process Chemistry
Pfizer
4 months ago
On-site
Bothell, WA
$124,400 - $201,400 USD yearly
Operations
Role Responsibilities
- Lead technical teams to design, execute, and interpret complex laboratory experiments for route development, process optimization, and scale-up.
- Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability.
- Lead authorship of patents, publications, and regulatory documents.
- Apply modern synthetic organic chemistry, high-throughput experimentation, mechanistic insight, and data-rich methods to accelerate development.
- Communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.
- Drive alignment to project timelines and portfolio strategy.
- Mentor junior staff and foster an inclusive, scientifically rigorous, collaborative environment.
- Lead technology transfer and partner interactions to enable external development campaigns.
- Build stakeholder relationships across process chemistry, partner functions, and project teams.
- Maintain an external technical presence through publications and presentations.
Basic Qualifications
- PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development (route design, scale-up, GMP manufacturing); or Master’s with 15+ years relevant experience.
- Deep understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification/analytical technologies.
- Demonstrated scientific impact via peer-reviewed publications, patents, or conference presentations.
- Strong communication skills and collaborative leadership in cross-functional process development teams.
- Experience supporting development from preclinical through commercial stages.
- Experience in regulated pharmaceutical environments, including GMP operations and authoring regulatory submissions.
- On-site role (5 days/week).
- Submission of a research summary is required.
Preferred Qualifications
- Experience developing drug-linkers for ADCs, PROTACS, DACs, or other targeted mixed-modality therapeutics.
- Experience mentoring and developing scientific staff.
- Experience with technology transfer and oversight of external development work.
- Experience at innovator pharmaceutical companies strongly preferred.
Application Instructions
- Submission of a research summary is required.
- Lead technical teams to design, execute, and interpret complex laboratory experiments for route development, process optimization, and scale-up.
- Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability.
- Lead authorship of patents, publications, and regulatory documents.
- Apply modern synthetic organic chemistry, high-throughput experimentation, mechanistic insight, and data-rich methods to accelerate development.
- Communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.
- Drive alignment to project timelines and portfolio strategy.
- Mentor junior staff and foster an inclusive, scientifically rigorous, collaborative environment.
- Lead technology transfer and partner interactions to enable external development campaigns.
- Build stakeholder relationships across process chemistry, partner functions, and project teams.
- Maintain an external technical presence through publications and presentations.
Basic Qualifications
- PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development (route design, scale-up, GMP manufacturing); or Master’s with 15+ years relevant experience.
- Deep understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification/analytical technologies.
- Demonstrated scientific impact via peer-reviewed publications, patents, or conference presentations.
- Strong communication skills and collaborative leadership in cross-functional process development teams.
- Experience supporting development from preclinical through commercial stages.
- Experience in regulated pharmaceutical environments, including GMP operations and authoring regulatory submissions.
- On-site role (5 days/week).
- Submission of a research summary is required.
Preferred Qualifications
- Experience developing drug-linkers for ADCs, PROTACS, DACs, or other targeted mixed-modality therapeutics.
- Experience mentoring and developing scientific staff.
- Experience with technology transfer and oversight of external development work.
- Experience at innovator pharmaceutical companies strongly preferred.
Application Instructions
- Submission of a research summary is required.