Senior Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics

Role: Senior Principal Scientist in Preclinical Safety & Translational Sciences, specializing in Pharmacokinetics & Pharmacodynamics, to support drug discovery programs. Responsibilities: apply PK/PD modeling to inform candidate selection, dosing, and project decisions from early discovery through clinical phases; contribute to modeling strategies and simulation approaches; collaborate with multidisciplinary teams including biology and chemistry to design informative preclinical and early clinical studies. Requirements: PhD in Pharmacology, Engineering, Mathematics, Physics, or related field with 6+ years (PhD) or 8+ years (Master's) industry experience; strong knowledge of pharmacokinetics, pharmacodynamics, and modeling; peer-reviewed publications in modeling are desirable; excellent communication and teamwork skills. HighValue: role focuses on physiologically-based PK/PD modeling, mechanistic modeling, and systems pharmacology to optimize clinical translation. Location: Spring House, PA or La Jolla, CA. Travel: not specified. The position supports biopharma drug development efforts in Innovative Medicine, emphasizing early translational sciences to guide candidate progression.