Senior Principal Scientist, Pharmacokinetics

Role: Senior Principal Scientist leading DMPK efforts in drug conjugate discovery and development, supporting strategic decision-making and advancing capabilities in emerging modalities. Responsibilities: provide scientific leadership for DMPK and ADME strategies, oversee experimentation, contribute to portfolio management, author regulatory documents, and manage a team of investigators and experts. Collaborate across discovery biology, translational sciences, clinical development, and external partners to ensure data-driven program progression from early discovery through clinical candidate nomination and FIH. Requirements: PhD or Master’s with 12+ or 15+ years' experience in pharmacokinetics, drug metabolism, bioanalytical sciences, or related fields; deep expertise in ADME, PK/PD, biologics/conjugates, and translational science; proven leadership in cross-functional teams and regulatory interactions. High-Value: biologics, conjugates, emerging modalities, translational PK/PD, nonclinical-to-clinical translation, regulatory submissions, early to late-stage development. WorkSetup: on-site in South San Francisco with approximately 10% travel.