Senior Principal Scientist, Discovery Chemistry

Role Summary

Accomplished medicinal chemist aiming to lead and contribute to the BMS portfolio as an integral member of the Global Discovery Chemistry (GDC) organization, based in San Diego

Responsibilities

• Lead and contribute to rational design of new agents for potential treatment of diverse oncology indications within the Protein Homeostasis Thematic Research Center portfolio.
• Collaborate with a broad group of scientists within the Discovery and Development Sciences group to advance projects from inception to IND.
• Apply modern drug design principles to solve medicinal chemistry problems and advance drug discovery programs.
• Mentor PhD and/or MSc/BSc-level scientists to high levels of productivity and develop direct reports through mentorship and development activities.
• Present rationale, key data, issues, and accomplishments of chemistry efforts to other members of the R&ED organization.

Qualifications

• Ph.D. in synthetic organic chemistry with 6+ years pharmaceutical medicinal chemistry industrial experience (8+ years preferred) or
• M.S. in synthetic organic chemistry with 8+ years pharmaceutical medicinal chemistry industrial experience (10+ years preferred) or
• B.S. in synthetic organic chemistry with 10+ years pharmaceutical medicinal chemistry industrial experience (12+ years preferred)
• Previous experience supporting and advancing target protein degradation and/or antibody-drug conjugate programs is preferred.
• Demonstrated ability to contribute and advance drug discovery programs with strong proficiency in fundamental aspects of drug discovery are required
• Track record of innovation and impact on programs documented through co-inventorship on issued patents and authorship of publications in peer-reviewed journals is necessary
• Strong working knowledge of protein-ligand interactions, ADME, conformational and structural analysis, and collaboration with computational chemists using AI/ML and predictive tools
• High level of creativity and productivity with strong synthetic productivity, problem-solving skills, synthetic methods, and reaction mechanisms
• Ability to champion chemistry efforts into new directions to achieve project milestones
• Strong skills in gathering, documenting, and analyzing information from competitive sources to guide program strategy
• Proven leadership capability in cross-functional teams
• Proven track record of mentoring scientists to high productivity and developing their skills
• Excellent communication skills to present chemistry efforts to R&ED organization

Skills

• Medicinal chemistry
• Drug design
• Protein-ligand interactions
• ADME and structural analysis
• Computational chemistry collaboration (AI/ML, predictive tools)
• Leadership and mentoring
• Cross-functional teamwork

Education

• Ph.D. preferred; other listed degree paths with corresponding experience acceptable