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Senior Principal Scientist, Clinical Research, Thoracic Malignancies

Merck
August 22, 2026
Full-time
Remote friendly (North Wales, PA)
Worldwide
Clinical Research and Development
Role: Senior Director (Sr. Principal Scientist) overseeing clinical research for Oncology medicines across all phases, from preclinical to post-licensure. Responsibilities include developing clinical strategies, designing and monitoring trials, analyzing safety and efficacy data, and contributing to regulatory submissions and publications. The role involves supervising Clinical Scientists, collaborating with cross-functional teams in regulatory, manufacturing, and commercialization, and engaging with external investigators and scientific communities. Qualifications: M.D. or M.D./Ph.D., minimum 3 years in clinical medicine, plus 3 years in industry or academia drug development, with a proven track record in oncology research. Preferred: Board certification in Oncology, prior clinical research publication. Skills required: expertise in cancer research, clinical trial design, and cross-functional teamwork. High-Value specifics: Oncology focus, clinical development stage from preclinical to post-market, involvement in investigational or marketed drugs, with approximately 25% travel and hybrid work setup.