Senior Principal Scientist, Clinical Research, Thoracic Malignancies
Merck
August 22, 2026
Remote friendly (North Wales, PA)
United States
Clinical Research and Development
Senior Director (Sr. Principal Scientist) – Oncology Clinical Development
Responsibilities:
- Plan and direct clinical research for new or marketed Oncology medicines across the clinical development lifecycle (study design, placement, monitoring, analysis, regulatory reporting, publication).
- Evaluate pre-clinical/translational work to generate early clinical development plans and IND applications.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor/manage ongoing or new clinical trials; analyze/summarize findings to support safety/efficacy decisions and drug applications, clinical study reports, or publications.
- Participate in internal and joint internal/external research teams for new and marketed compounds.
- Supervise Clinical Scientists; partner with commercialization, regulatory affairs, statistics, and manufacturing.
- Maintain scientific knowledge (track developments, identify investigators, engage clinical experts, attend scientific meetings).
- Author development documents/budgets/papers; facilitate global collaborations; travel ~20%.
Qualifications:
- Education: M.D. or M.D./Ph.D.
- Required: Industry or senior faculty academia experience; 3+ years clinical medicine; 3+ years industry drug development or biomedical research in academia; strong scholarship; proven clinical medicine + biomedical research background; strong interpersonal/team skills; outstanding verbal/written communication and presentation.
- Preferred: Board Certified/Eligible in Oncology; prior clinical research experience and publication.
Skills (required): Cancer Research, Clinical Development, Clinical Trials, Cross-Functional Teamwork, Drug Development, Oncology Trials.
Preferred skills: Not specified (application via links below).
Benefits/Compensation (as stated): Annual bonus and long-term incentive (if applicable); comprehensive benefits incl. medical/dental/vision, retirement/401(k), paid holidays, vacation, compassionate and sick days.
Application:
- Apply at https://jobs.merck.com/us/en (or via Workday Jobs Hub). Application deadline is on the posting; Job Posting End Date: 09/10/2026.
Responsibilities:
- Plan and direct clinical research for new or marketed Oncology medicines across the clinical development lifecycle (study design, placement, monitoring, analysis, regulatory reporting, publication).
- Evaluate pre-clinical/translational work to generate early clinical development plans and IND applications.
- Develop clinical development strategies and plan clinical trials (design, operational plans, settings).
- Monitor/manage ongoing or new clinical trials; analyze/summarize findings to support safety/efficacy decisions and drug applications, clinical study reports, or publications.
- Participate in internal and joint internal/external research teams for new and marketed compounds.
- Supervise Clinical Scientists; partner with commercialization, regulatory affairs, statistics, and manufacturing.
- Maintain scientific knowledge (track developments, identify investigators, engage clinical experts, attend scientific meetings).
- Author development documents/budgets/papers; facilitate global collaborations; travel ~20%.
Qualifications:
- Education: M.D. or M.D./Ph.D.
- Required: Industry or senior faculty academia experience; 3+ years clinical medicine; 3+ years industry drug development or biomedical research in academia; strong scholarship; proven clinical medicine + biomedical research background; strong interpersonal/team skills; outstanding verbal/written communication and presentation.
- Preferred: Board Certified/Eligible in Oncology; prior clinical research experience and publication.
Skills (required): Cancer Research, Clinical Development, Clinical Trials, Cross-Functional Teamwork, Drug Development, Oncology Trials.
Preferred skills: Not specified (application via links below).
Benefits/Compensation (as stated): Annual bonus and long-term incentive (if applicable); comprehensive benefits incl. medical/dental/vision, retirement/401(k), paid holidays, vacation, compassionate and sick days.
Application:
- Apply at https://jobs.merck.com/us/en (or via Workday Jobs Hub). Application deadline is on the posting; Job Posting End Date: 09/10/2026.