Senior Principal Scientist - Bioanalytical Research
Eli Lilly and Company
August 23, 2026
Remote friendly (Louisville, CO)
United States
Clinical Research and Development
The Bioanalytical Research Group (BAR) in Investigative ADME/Toxicology and BioAnalytical Research (Louisville, CO) is seeking an expert scientist skilled in small and large molecule mass spectrometry to support Lilly’s oncology portfolios, with emphasis on bioanalysis of small molecule drug (especially radioligand therapeutics, RLT) and potential expansion into antibody-drug conjugates (ADC).
Responsibilities:
- Perform sample preparation (tissue homogenization, multiwave digestion, immunoaffinity enrichment, protein precipitation) and operate mass spectrometer to develop bioanalytical methods and conduct quantitative bioanalysis (bioA) from in-vitro and in-vivo samples.
- Investigate SAR including PK, biodistribution, biotransformation, and metabolite identification using LC-MS/MS.
- Collaborate with ADME project leaders; serve as bioA representative and provide bioanalytical expertise.
- Mentor junior scientists in LC-MS sample prep, data analysis, visualization, and reporting.
- Maintain and troubleshoot lab instruments.
Job Requirements:
- BS in science/engineering (chemistry/chemical engineering/bioengineering or related) + 7 years; or MS + 5 years.
- Experience with ICP, triple quadrupole (QQQ), and high-resolution MS (QToF, Orbitrap) for bioA method development, qualification, and transfer.
- Small/large molecule bioanalysis experience (tissue homogenization, microwave acid digestion; LLE, SPE, immunoprecipitation, protein precipitation).
- ADME knowledge (PK, biodistribution, biotransformation).
- Authorized to work in the United States full-time; no work authorization/visa sponsorship.
Preferred Qualifications:
- Radioligand therapeutics and elemental analysis using Agilent 8900 ICP-MS; LC-MS bioanalytical workflow for RLT bioA/metID.
- Biotherapeutics workflows (mAbs/ADC/siRNA/fusion proteins), immunoprecipitation, proteolytic digestion/deglycosylation; peptide/payload quantification (Sciex 6500/7500); intact mass and top-down MS (Orbitrap Exploris instruments).
- MS informatics tools (Mass Hunter, Biopharma Finder, QuantBrowser, MultiQuant, etc.); AI-based analysis/reporting.
- eLN/experiment documentation; PK calculation (Phoenix, Watson LIMS, R-studio aNCA); visualization (PRISM, BioRender); report QC.
- Automation instruments (Apricot, Hamilton, Tecan, KingFisher) for high-throughput assays.
Benefits:
- Eligibility for a company bonus (based on company/individual performance).
- Comprehensive benefits: 401(k) + pension; vacation; medical/dental/vision/prescription; flexible benefits; life insurance/death benefits; time off/leave; well-being benefits.
Application Instructions:
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.
Responsibilities:
- Perform sample preparation (tissue homogenization, multiwave digestion, immunoaffinity enrichment, protein precipitation) and operate mass spectrometer to develop bioanalytical methods and conduct quantitative bioanalysis (bioA) from in-vitro and in-vivo samples.
- Investigate SAR including PK, biodistribution, biotransformation, and metabolite identification using LC-MS/MS.
- Collaborate with ADME project leaders; serve as bioA representative and provide bioanalytical expertise.
- Mentor junior scientists in LC-MS sample prep, data analysis, visualization, and reporting.
- Maintain and troubleshoot lab instruments.
Job Requirements:
- BS in science/engineering (chemistry/chemical engineering/bioengineering or related) + 7 years; or MS + 5 years.
- Experience with ICP, triple quadrupole (QQQ), and high-resolution MS (QToF, Orbitrap) for bioA method development, qualification, and transfer.
- Small/large molecule bioanalysis experience (tissue homogenization, microwave acid digestion; LLE, SPE, immunoprecipitation, protein precipitation).
- ADME knowledge (PK, biodistribution, biotransformation).
- Authorized to work in the United States full-time; no work authorization/visa sponsorship.
Preferred Qualifications:
- Radioligand therapeutics and elemental analysis using Agilent 8900 ICP-MS; LC-MS bioanalytical workflow for RLT bioA/metID.
- Biotherapeutics workflows (mAbs/ADC/siRNA/fusion proteins), immunoprecipitation, proteolytic digestion/deglycosylation; peptide/payload quantification (Sciex 6500/7500); intact mass and top-down MS (Orbitrap Exploris instruments).
- MS informatics tools (Mass Hunter, Biopharma Finder, QuantBrowser, MultiQuant, etc.); AI-based analysis/reporting.
- eLN/experiment documentation; PK calculation (Phoenix, Watson LIMS, R-studio aNCA); visualization (PRISM, BioRender); report QC.
- Automation instruments (Apricot, Hamilton, Tecan, KingFisher) for high-throughput assays.
Benefits:
- Eligibility for a company bonus (based on company/individual performance).
- Comprehensive benefits: 401(k) + pension; vacation; medical/dental/vision/prescription; flexible benefits; life insurance/death benefits; time off/leave; well-being benefits.
Application Instructions:
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.