Senior Principal Scientist, Analytical Sciences
Eli Lilly and Company
August 11, 2026
On-site
Watertown, MA
Clinical Research and Development
Responsibilities:
- Implement and refine analytical testing strategies for circular RNA and lipid nanoparticle (LNP) formulations.
- Develop and optimize drug substance and drug product LC-MS/MS assays for quantification and characterization; perform in-depth characterization studies for lead candidates and pipeline programs.
- Troubleshoot complex hardware and software issues on high-resolution MS platforms.
- Lead method transfer activities to external partners, providing technical oversight, troubleshooting, and ensuring assay robustness and compliance.
- Author and review methods, reports, and SOPs to ensure alignment with regulatory expectations.
- Generate high-quality data packages; analyze, interpret, and present findings to cross-functional R&D teams.
- Foster a positive, innovative, entrepreneurial team culture; contribute to scientific strategy and continuous improvement.
Qualifications (Basic Requirements):
- M.S. or B.S. in molecular biology, cell biology, biochemistry, or chemistry plus assay development experience: 7+ years LC-MS (M.S.) or 10+ years LC-MS (B.S.).
- PhD will not be considered at this job level.
- Full competency in bioanalysis by LC-MS/MS (method development, quantitative assay execution, data review, scientific communication).
- Hands-on expertise with complex LC-MS operations and maintenance of QTOF, Orbitrap, or triple quadrupole MS.
- Experience with IP-RP, AEX, SEC-MALS, and LC-CAD for characterization and release testing of RNA, lipids, and proteins in complex matrices.
- Authorized to work in the United States full-time; visa/work authorization sponsorship not provided.
Additional Preferences:
- Experience in RNA biology or RNA therapeutics.
- Excellent oral and written communication of complex data.
- Knowledge of CMC and regulatory requirements (ICH Quality Guidelines; cGMP).
- Strong problem-solving and interpersonal skills in a fast-paced environment.
- Implement and refine analytical testing strategies for circular RNA and lipid nanoparticle (LNP) formulations.
- Develop and optimize drug substance and drug product LC-MS/MS assays for quantification and characterization; perform in-depth characterization studies for lead candidates and pipeline programs.
- Troubleshoot complex hardware and software issues on high-resolution MS platforms.
- Lead method transfer activities to external partners, providing technical oversight, troubleshooting, and ensuring assay robustness and compliance.
- Author and review methods, reports, and SOPs to ensure alignment with regulatory expectations.
- Generate high-quality data packages; analyze, interpret, and present findings to cross-functional R&D teams.
- Foster a positive, innovative, entrepreneurial team culture; contribute to scientific strategy and continuous improvement.
Qualifications (Basic Requirements):
- M.S. or B.S. in molecular biology, cell biology, biochemistry, or chemistry plus assay development experience: 7+ years LC-MS (M.S.) or 10+ years LC-MS (B.S.).
- PhD will not be considered at this job level.
- Full competency in bioanalysis by LC-MS/MS (method development, quantitative assay execution, data review, scientific communication).
- Hands-on expertise with complex LC-MS operations and maintenance of QTOF, Orbitrap, or triple quadrupole MS.
- Experience with IP-RP, AEX, SEC-MALS, and LC-CAD for characterization and release testing of RNA, lipids, and proteins in complex matrices.
- Authorized to work in the United States full-time; visa/work authorization sponsorship not provided.
Additional Preferences:
- Experience in RNA biology or RNA therapeutics.
- Excellent oral and written communication of complex data.
- Knowledge of CMC and regulatory requirements (ICH Quality Guidelines; cGMP).
- Strong problem-solving and interpersonal skills in a fast-paced environment.