Senior Principal Research Scientist, Protein Sciences

Role: Senior Principal Research Scientist in Protein Sciences at IDEAYA Biosciences, focused on developing and optimizing recombinant protein expression and purification strategies to support drug discovery programs. Responsibilities: conduct hands-on protein production using bacterial and insect-cell systems, troubleshoot challenging proteins and complexes, supervise and mentor research staff, coordinate with external CROs for protein characterization, and collaborate with multidisciplinary teams across Biochemistry, Structural Biology, Bioassays, and Data Science to translate experimental results into program decisions. Requirements: PhD with 9+ years of experience in recombinant protein production, proficiency in bacterial and insect-cell expression systems, expertise in protein purification, characterization, and troubleshooting, and experience managing external partners. Preferred: knowledge of mammalian expression, proteomics, chemoproteomics, or chemical biology. The role involves onsite work in South San Francisco, with minimal travel (<1%). High-value specifics include involvement in biologics and protein complex development for oncology drug discovery, supporting multiple therapeutic modalities in preclinical stages. The role reports to the Vice President, Lead Discovery, and aims to contribute to IDEAYA’s pipeline of targeted therapies for solid tumors, with a focus on synthetic lethality and ADCs.