Senior Principal Computational Geneticist

Role Summary

Human genetics has established itself as a cornerstone of modern drug discovery, yet we are only beginning to unlock the full potential of the rich biomedical data now being generated.

We are seeking a geneticist with a passion for applying cutting-edge approaches, including genetic epidemiology, quantitative genetics, computational biology, AI, functional omics, epigenetics, and other multi-omics data resources, to accelerate the identification of causal mechanisms, therapeutic indications, biomarkers, and patient stratification strategies. The ideal candidate will have demonstrated leadership of managing cross-functional teams to integrate multi-modal omics data with biologic information to help drive target identification.

The Integrative Biology team within the Internal Medicine Research Unit works closely with disease area biologists to address unmet medical needs in metabolic diseases, including obesity and cardiovascular disease, with a particular focus on atherosclerotic cardiovascular disease. We do this by developing and applying advanced methods to analyze human genetics and other large-scale molecular datasets.

In addition, we collaborate with AI and machine learning teams to develop methods and tools that enhance our ability to work with and interpret complex genetics and genomics data. These tools help deliver meaningful insights and actionable recommendations to disease area project teams.

The ideal candidate for this role will have experience leading external partnerships, including developing and building external collaborations and managing relationships with external partners to ensure the timely delivery of high-quality genetics and genomics data, and to incorporate results into target identification and validation.

The applied human genetics scientist position offers an opportunity to execute science-based drug discovery within one of the world’s leading developers of human therapeutics, at Pfizer’s Kendall Square research facility in Cambridge Massachusetts.

Role Responsibilities

• Provide quantitative genetics expertise and conduct analyses to derive impactful results through interactions with biologists within the Internal Medicine Research Unit.
• Provide expertise and quantitative skills on the application of genetics and functional genomics to inform project teams in:
• Identification of novel therapeutic targets
• Review and validation of therapeutic hypotheses
• Mechanistic understanding of disease pathogenesis and causal pathways
• Innovative approaches to identifying mechanism related biomarkers via integrating genetics with clinical and 'omic datasets.
• Identification of potential disease indications.
• Matching novel therapies to patients with relevant disease sub-types.
• Develop and lead cross-functional teams in statistics, bioinformatics, computational biology, clinicians to ensure high-quality genetic and ‚Äòomics data is integrated into incorporated into exploratory research.
• Work with our partners in machine learning and AI to build tools that provide genetics / genomics results to our scientists and other stakeholders.
• Work in collaboration with research biologists and project teams to identify the best opportunities to translate genetic and related data to inform and prioritize assets in the portfolio; and with clinical teams to inform optimum patient selection, stratification and trial design.
• Develop and build high-value external collaborations; Manage and maintain internal and external collaborative projects to specified timelines and milestones.
• Communicate study findings and analyses with internal partners, leadership, administration, and collaborators.
• Manage, support and promote relationships with the external community that can add value to target selection and validation at Pfizer
• Willingness to learn new skills and be ‚Äúchange agile‚Äù

Qualifications

• Background in biological and/or quantitative sciences; PhD required and post-doctoral experience in genetics, statistical genetics, or genetic epidemiology with at least five (5) years relevant experience
• Sound statistical and quantitative skills, with knowledge of epidemiological principals and population-based research.
• Experience developing and managing large projects, collaborations, or consortia
• Evidence of scientific leadership role with responsibility for research project delivery
• Experience analyzing genetic data sets and integrating additional data types to further clinical and biological understanding; Experience in at least one other ‚Äòomics technologies (e.g. metabolomics, lipidomics, transcriptomics, epigenetics)
• Track record of innovative and impactful research in genetics of complex traits, including peer-reviewed publications.
• Use of generative AI tools such as Microsoft copilot, github copilot, ChatGPT, Claude, Gemini, etc.
• Deep and abiding curiosity about biological and pathological processes and mechanisms.
• Proficiency in programming, scripting, querying or statistical analysis languages such as R, python, perl, SQL.
• Familiarity with genetics platforms
• Able to effectively interact and communicate with multidisciplinary scientists, researchers, and non-scientists- internally and externally; excellent communication, interpersonal, and presentation skills essential
• Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Physical/Mental Requirements

Mathematical calculations and complex data analysis required

Additional Information

• Relocation support available
• Work Location Assignment: This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week.
• Last Day to Apply: November 12, 2025