Senior Medical Director, Translational Medicine & Early Clinical Development (MD)
Madrigal Pharmaceuticals
August 12, 2026
Remote friendly (Conshohocken, PA)
United States
Clinical Research and Development
Senior Medical Director, Translational Medicine & Early Clinical Development
Key Responsibilities
- Serve as global medical lead/medical monitor for early phase studies (e.g., FIH, PoC, mechanistic, and indication-expansion trials in MASH and related cardiometabolic/liver conditions).
- Lead study concept/protocol design, including patient populations, clinical and biomarker endpoints, and mechanistic sub-studies.
- Provide ongoing medical oversight (eligibility review, safety monitoring, dose decision-making, interpretation of emerging data).
- Partner with Clinical Operations and CROs for high-quality execution, timely data delivery, and inspection-readiness.
- Define and own translational strategy for assigned programs (preclinical to late-stage), ensuring alignment between nonclinical and clinical plans.
- Integrate PK/PD, biomarkers, imaging, and clinical outcomes to develop a mechanistic narrative and inform dose/regimen selection.
- Oversee clinical biomarker plans and drive biospecimen banking and downstream analyses.
- Chair/co-chair early asset teams/translational working groups; define objectives, deliverables, and decision points.
- Provide clinical/mechanistic input into key documents (IB, CSR, TS/TPPs, regulatory briefing materials, publications, presentations).
- Present program/mechanistic work at internal governance forums and, as appropriate, to Executive Team/Board.
- Build external expert relationships and lead/co-lead scientific collaborations; represent the company at scientific/medical conferences.
- Provide day-to-day leadership/mentoring for junior physicians and PhD scientists; refine the Translational Medicine operating model.
Qualifications
- MD with clinical training in hepatology, gastroenterology, endocrinology, cardiology, internal medicine, or equivalent.
- 15+ years relevant industry experience in clinical development, including leadership of early phase interventional trials.
- Strong track record in translational medicine and biomarker-driven development; metabolic liver or cardiometabolic disease experience strongly preferred.
- Regulatory interaction experience on early development/biomarker topics highly desirable.
- Ability to lead cross-functional teams, influence without authority, and communicate complex mechanistic concepts to diverse stakeholders.
- Hybrid opportunity based in Conshohocken, PA or Waltham, MA offices.
Benefits
- Full-time employees: base pay, bonus, equity, flexible paid time off, medical, dental, vision, life/disability insurance, and 401(k) (traditional, Roth, employer match).
- Additional voluntary benefits may include supplemental life insurance and legal services.
Application Instructions
- Applications accepted on an ongoing basis via the Madrigal Careers site.
Key Responsibilities
- Serve as global medical lead/medical monitor for early phase studies (e.g., FIH, PoC, mechanistic, and indication-expansion trials in MASH and related cardiometabolic/liver conditions).
- Lead study concept/protocol design, including patient populations, clinical and biomarker endpoints, and mechanistic sub-studies.
- Provide ongoing medical oversight (eligibility review, safety monitoring, dose decision-making, interpretation of emerging data).
- Partner with Clinical Operations and CROs for high-quality execution, timely data delivery, and inspection-readiness.
- Define and own translational strategy for assigned programs (preclinical to late-stage), ensuring alignment between nonclinical and clinical plans.
- Integrate PK/PD, biomarkers, imaging, and clinical outcomes to develop a mechanistic narrative and inform dose/regimen selection.
- Oversee clinical biomarker plans and drive biospecimen banking and downstream analyses.
- Chair/co-chair early asset teams/translational working groups; define objectives, deliverables, and decision points.
- Provide clinical/mechanistic input into key documents (IB, CSR, TS/TPPs, regulatory briefing materials, publications, presentations).
- Present program/mechanistic work at internal governance forums and, as appropriate, to Executive Team/Board.
- Build external expert relationships and lead/co-lead scientific collaborations; represent the company at scientific/medical conferences.
- Provide day-to-day leadership/mentoring for junior physicians and PhD scientists; refine the Translational Medicine operating model.
Qualifications
- MD with clinical training in hepatology, gastroenterology, endocrinology, cardiology, internal medicine, or equivalent.
- 15+ years relevant industry experience in clinical development, including leadership of early phase interventional trials.
- Strong track record in translational medicine and biomarker-driven development; metabolic liver or cardiometabolic disease experience strongly preferred.
- Regulatory interaction experience on early development/biomarker topics highly desirable.
- Ability to lead cross-functional teams, influence without authority, and communicate complex mechanistic concepts to diverse stakeholders.
- Hybrid opportunity based in Conshohocken, PA or Waltham, MA offices.
Benefits
- Full-time employees: base pay, bonus, equity, flexible paid time off, medical, dental, vision, life/disability insurance, and 401(k) (traditional, Roth, employer match).
- Additional voluntary benefits may include supplemental life insurance and legal services.
Application Instructions
- Applications accepted on an ongoing basis via the Madrigal Careers site.